Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 <20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.
Description | SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells. |
Synonyms | SU-11652, SU 11652 |
Molecular Weight | 414.93 |
Formula | C22H27ClN4O2 |
CAS No. | 326914-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SU11652 326914-10-7 SU-11652 SU 11652 inhibitor inhibit