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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T9998 | MIND4-19 | Sirtuin | |
MIND4-19 is an inhibitor of SIRT2 with antitumor activity. | |||
T0412 | Idebenone | CV-2619 | Apoptosis , Antioxidant , Mitochondrial Metabolism |
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). | |||
T6111 | Selisistat | EX-527,SEN0014196 | Sirtuin |
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea. | |||
T3206 | NKL 22 | Histone Deacetylase Inhibitor IV,PAOA | HDAC |
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. | |||
TP2417 | Tidembersat | Others | |
Tidembersat is a small molecule compound used to treat and/or prevent degenerative diseases such as Huntington's chorea, schizophrenia, neurological. | |||
T9159 | PBT-1033 | PB 1033,PBT1033,PBT-2,PBT 2,PBT2 | Others |
PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease. | |||
T62839 | Dalzanemdor | SAGE-718 | NMDAR , iGluR |
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction. | |||
T15035 | Cystamine | 2,2'-Disulfanediyldiethanamine | Caspase |
Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases. | |||
T61859 | MK-28 | Antiviral , PERK | |
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells. | |||
T22595 | B2 | Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline | Others , Sirtuin |
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease | |||
T23331 | SC 51089 | SC 51089 free base | Prostaglandin Receptor |
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... | |||
T38605 | NCT-504 | Others | |
NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease. | |||
T2075 | Pyrazolo[1,5-a]pyrimidine 4h | Others | |
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore... | |||
T9340 | 1-phenyl-3,4-dihydroisochinoline | 3,4-Dihydro-1-phenylisoquinoline | Others |
1-phenyl-3,4-dihydroisochinoline is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a potential therapeutic agent for the ... | |||
T13133 | Tetrabenazine Metabolite | (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ | Monoamine Transporter |
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben... | |||
T75319 | Taurodeoxycholic acid | Taurodeoxychloic acid | Apoptosis , Calcium Channel , Caspase |
Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic a... | |||
T40652 | Meclizine | Meclozine | Histamine Receptor |
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... | |||
T28363 | PF-02545920 | ||
PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease. | |||
T39480 | Lexanersen | WVE-120102,Lexanersen | |
Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research. |