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Search Results for " huntington's "

20

Compounds

Cat No. Product Name Synonyms Targets
T8452 Dantrolene Others
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
T9998 MIND4-19 Sirtuin
MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
T0412 Idebenone CV-2619 Apoptosis , Antioxidant , Mitochondrial Metabolism
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
T6111 Selisistat EX-527,SEN0014196 Sirtuin
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.
T3206 NKL 22 Histone Deacetylase Inhibitor IV,PAOA HDAC
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
TP2417 Tidembersat Others
Tidembersat is a small molecule compound used to treat and/or prevent degenerative diseases such as Huntington's chorea, schizophrenia, neurological.
T9159 PBT-1033 PB 1033,PBT1033,PBT-2,PBT 2,PBT2 Others
PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T62839 Dalzanemdor SAGE-718 NMDAR , iGluR
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
T15035 Cystamine 2,2'-Disulfanediyldiethanamine Caspase
Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.
T61859 MK-28 Antiviral , PERK
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.
T22595 B2 Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline Others , Sirtuin
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
T23331 SC 51089 SC 51089 free base Prostaglandin Receptor
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's...
T38605 NCT-504 Others
NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.
T2075 Pyrazolo[1,5-a]pyrimidine 4h Others
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore...
T9340 1-phenyl-3,4-dihydroisochinoline 3,4-Dihydro-1-phenylisoquinoline Others
1-phenyl-3,4-dihydroisochinoline is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a potential therapeutic agent for the ...
T13133 Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ Monoamine Transporter
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben...
T75319 Taurodeoxycholic acid Taurodeoxychloic acid Apoptosis , Calcium Channel , Caspase
Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic a...
T40652 Meclizine Meclozine Histamine Receptor
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ...
T28363 PF-02545920
PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease.
T39480 Lexanersen WVE-120102,Lexanersen
Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research.
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