Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chorea.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 61.00 | |
5 mg | In stock | $ 109.00 | |
10 mg | In stock | $ 193.00 | |
25 mg | In stock | $ 345.00 | |
50 mg | In stock | $ 512.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 148.00 |
Description | Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chorea. |
In vivo | Only Parthenolide, the HDAC inhibitor with anti-inflammatory features, displayed a potent anti-apoptotic effect in Phb1 KO hepatocytes. Indeed, TSA and Parthenolide-treated hepatocytes showed increased levels of FXR, and reduced levels of CYP7A1, HDAC4, TNFα, TRAIL and Bax suggesting a less toxic effect of bile acids as a results of specific HDAC inhibition, resulting in the attenuation of the Phb1 KO hepatocytes apoptotic response. Importantly, Parthenolide exerts a protective effect from the liver injury after BDL in Phb1 KO mice. Indeed, Parthenolide treatment results in a reduction of the mortality rate of this mice after BDL associated with a lower apoptotic response as revealed by a reduction of necrotic areas, Tunel-staining, as well as decreased ALT (8431±957 vs.4225±210 U/L) and AST (4805±300 vs.2242±438 U/L) activities compared to control Phb1 KO mice[3]. |
Molecular Weight | 401.46 |
Formula | C23H23N5O2 |
CAS No. | 597544-21-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (62.27 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Pyrazolo[1,5-a]pyrimidine 4h 597544-21-3 Others Pyrazolo[1,5a]pyrimidine 4h Pyrazolo[1,5 a]pyrimidine 4h inhibitor inhibit