Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 32.00 | |
25 mg | In stock | $ 50.00 | |
50 mg | In stock | $ 72.00 | |
100 mg | In stock | $ 98.00 | |
500 mg | In stock | $ 278.00 |
Description | Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases. |
Targets&IC50 | Caspase-3:23.6 μM |
In vitro | In human neuroblastoma SH-SY5Y cells, Cystamine inhibits the MG132-mediated and H2O2-mediated activation of caspase-3 in a concentration-dependent manner. Cystamine (250 μM) robustly results in an increasement of the glutathione level[1]. |
In vivo | In R6/2 transgenic HD mice, oral and intraperitoneal administration of Cystamine (112-225 mg/kg) reduces the levels of transglutaminase and N(Sigma)-(gamma-L-glutamyl)-L-lysin. Cystamine extends survival and improves body weight and motor performance[2]. |
Synonyms | 2,2'-Disulfanediyldiethanamine |
Molecular Weight | 152.28 |
Formula | C4H12N2S2 |
CAS No. | 51-85-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (591.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cystamine 51-85-4 Apoptosis Proteases/Proteasome Caspase 2,2'-Disulfanediyldiethanamine inhibitor inhibit