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Cat No. | Product Name | Synonyms | Targets |
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T5858 | Sertindole | Lu 23-174 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy |
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) | |||
T22534 | 8-Hydroxy-DPAT hydrobromide | 8-OH-DPAT hydrobromide | 5-HT Receptor |
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype... | |||
T10170 | 5-HT7 agonist 1 | 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole | 5-HT Receptor |
5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders. | |||
T2395L | Vortioxetine hydrobromide | Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide | 5-HT Receptor , Serotonin Transporter |
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM). | |||
T2283 | PX-12 | IV-2,PX12 | Thioredoxin |
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr... | |||
T61724 | SB 258741 hydrochloride | ||
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1]. | |||
T39870 | 5-HT7R antagonist 1 free base | 5-HT7R antagonist 1 free base | |
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM. | |||
T62503 | EGFR/BRAFV600E-IN-1 | ||
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent dual inhibitor of EGFR (IC50: 0.08 μM) and BRAFV600E (IC50: 0.15 μM). EGFR/BRAFV600E-IN-1 exhibited anti-proliferative effects on A-549 (IC50: 1.2 μM), MCF-7 (IC50: 0.79 μM),... | |||
T35438 | (5E)-7-Oxozeaenol | ||
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxoz... | |||
T69589 | PX-316 | ||
PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor act... | |||
T27269 | Ensaculin HCl | KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl | |
Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and... | |||
T36318 | 28-Acetylbetulin | ||
28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced... | |||
T37167 | Reduced Haloperidol | ||
Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4... | |||
T36639 | Donecopride (fumarate hydrate) | ||
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ... | |||
T37114 | SB 242084 dihydrochloride | ||
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242... | |||
T16780 | Rodatristat | KAR5417 | Others |
Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively). |
Cat No. | Product Name | Synonyms | Targets |
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T6S0654 | Isocorynoxeine | 7-Isocorynoxeine | 5-HT Receptor |
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... | |||
T5S1607 | Morusin | Mulberrochromene | NF-κB , Antibacterial , STAT |
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti... | |||
TN1727 | Helichrysetin | Apoptosis , HIV Protease | |
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29. | |||
T5S0506 | Rotundic acid | Rutundic acid | Apoptosis , Others , p38 MAPK , Akt , mTOR |
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c... | |||
TN2030 | P-Hydroxyphenethyl trans-ferulate | 5-HT Receptor | |
P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level... | |||
T81857 | Marsdenoside A | ||
Marsdenoside A (compound 7), an isolated compound from the Alocasia genus, exhibits a weak inhibitory effect on the growth of two tumor cell lines, MGC-803 and HT-29, with IC50 values exceeding 50 μg/mL. | |||
TN3870 | Iriflophenone 2-O-Rhamnoside | Dimethylmatairesinol | Others |
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01315 | EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells |
EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 48.6 kDa and the accession number is P18572-2. | |||
TMPY-01316 | EMMPRIN/CD147 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
EMMPRIN/CD147 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30 kDa and the accession number is P18572-2. | |||
TMPY-06036 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) | Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7. | |||
TMPK-01371 | IGFBP-7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ... | |||
TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPK-00395 | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. | |||
TMPK-00828 | Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire... | |||
TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPK-00393 | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. | |||
TMPY-06035 | FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) | Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7. |
Cat No. | Product Name | ||
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L2800 | Serotonin Receptor-Targeted Compound Library | 268 compounds | |
A unique collection of 268 compounds targeting serotonin receptors for high throughput screening and high content screening; |