dengue — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4197	HZ-1157	HZ1157,DHFR-inhibitor	HCV Protease
	HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.		HCV Protease
T9618	HeE1-2Tyr		SARS-CoV
	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.		SARS-CoV
T23004	ML-SA1	Mucolipin synthetic agonist 1	Others , TRP/TRPV Channel
	ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV...		Others , TRP/TRPV Channel
T11760	KIN101	3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene	HCV Protease , Influenza Virus , RSV , Antifection
	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R...		HCV Protease , Influenza Virus , RSV , Antifection
T13397	ZINC03129319		Virus Protease
	ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.		Virus Protease
T8886	NITD-2		DNA/RNA Synthesis
	NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in hu...		DNA/RNA Synthesis
T64091	(-)-JNJ-A07		Others
	(-)-JNJ-A07 is a selective and potent dengue virus (DENV) inhibitor (EC50:31 nM) with antiviral activity for the study of dengue virus infections.		Others
T16914	SP187	UV4,MON-DNJ	Others , Virus Protease , Influenza Virus
	SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.		Others , Virus Protease , Influenza Virus
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
T16325	NITD008	7-Deaza-2'-C-acetylene-adenosine	Others
	NITD008 (7-Deaza-2'-C-acetylene-adenosine) is a potent and selective adenosine nucleoside inhibitor.NITD008 is an adenosine nucleoside analog with broad-spectrum antiviral activity that inhibits dengue, animal cupripoxvi...		Others
T63143	DENV-IN-5		Virus Protease , HIV Protease
	Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.		Virus Protease , HIV Protease
T17190	U18666A		Others , HCV Protease
	U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.		Others , HCV Protease
T16702	QL47		Virus Protease , BTK
	QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translation and a covalent inhibitor of BTK, and can be used in the s...		Virus Protease , BTK
T38960	QL-X-138		Virus Protease , MNK , BTK
	QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, MNK1 and MNK2 kinases are 9.4 nM, 107.4 nM and 26 nM, respe...		Virus Protease , MNK , BTK
T76856	Andecaliximab	GS-5745	MMP , Virus Protease
	Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used ...		MMP , Virus Protease
TN1065	Hirsutine		Apoptosis
	Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti...		Apoptosis
T11281L	FGI-106 tetrahydrochloride		Virus Protease , HCV Protease , Influenza Virus , HIV Protease
	FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective ...
T38960L	QL-X-138 HCl	QL-X-138 HCl（1469988-63-3 Free base）	MNK , BTK
	QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-1...		MNK , BTK
T24432	MB21	MB-21,MB 21
	MB21 is a dengue type 2 protease inhibitor that acts by inhibiting each one of the four serotypes of dengue viruses in infected cells in culture.
T69649	NITD-688
	NITD-688 is a pan-serotype inhibitor targeting the dengue virus NS4B protein, effective through oral administration. It holds potential in dengue virus (DENV) research applications.