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FGI-106 tetrahydrochloride

Catalog No. T11281L   CAS 1149348-10-6

FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.

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FGI-106 tetrahydrochloride Chemical Structure
FGI-106 tetrahydrochloride, CAS 1149348-10-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 383.00
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Purity: 98.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
Targets&IC50 Ebola virus:(EC50)100 nM , Dengue Fever virus: 400-900 nM , HIV-1:150 nM , HCV: 200 nM , Rift Valley virus: 800 nM
In vitro In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
In vivo FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
Molecular Weight 604.48
Formula C28H42Cl4N6
CAS No. 1149348-10-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.5 mg/ml (12.41 mM), Sonification is recommended

TargetMolReferences and Literature

1. Aman MJ, et al. Development of a broad-spectrum antiviral with activity against Ebola virus. Antiviral Res. 2009 Sep;83(3):245-51.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library Anti-Viral Compound Library

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Keywords

FGI-106 tetrahydrochloride 1149348-10-6 Microbiology/Virology Proteases/Proteasome HIV Protease Virus Protease HCV Protease Influenza Virus fever pathogens Ebola inhibit HIV-1 replication FGI 106 Tetrahydrochloride HCV hemorrhagic Hepatitis C virus EBOV HIV tetrahydrochloride FGI106 tetrahydrochloride FGI106 Tetrahydrochloride Inhibitor FGI-106 broad-spectrum antiviral Human immunodeficiency virus FGI-106 Tetrahydrochloride lethal FGI106 FGI 106 tetrahydrochloride FGI 106 inhibitor

 

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