KIN101

KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.

Catalog No. T11760Cas No. 610753-87-2

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Purity:99.46%

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COA HPLC HNMR

KIN101

Catalog No. T11760Cas No. 610753-87-2

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Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$43	In Stock
25 mg	$77	In Stock
50 mg	$128	In Stock
100 mg	$193	In Stock
200 mg	$287	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Product Introduction

Bioactivity

Description	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
Targets&IC50	DNV:>5 μM , Influenza virus:2 μM
In vitro	KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
Alias	3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

Chemical Properties

Molecular Weight	395.22
Formula	C₁₆H₁₁BrO₅S
Cas No.	610753-87-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 32 mg/mL (80.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5302 mL	12.6512 mL	25.3024 mL	126.5118 mL
5 mM	0.5060 mL	2.5302 mL	5.0605 mL	25.3024 mL
10 mM	0.2530 mL	1.2651 mL	2.5302 mL	12.6512 mL
20 mM	0.1265 mL	0.6326 mL	1.2651 mL	6.3256 mL
50 mM	0.0506 mL	0.2530 mL	0.5060 mL	2.5302 mL

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