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KIN101

KIN101
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
Catalog No. T11760Cas No. 610753-87-2
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Purity:99.46%
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KIN101

Catalog No. T11760Cas No. 610753-87-2
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
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Pack SizePriceAvailabilityQuantity
5 mg$29In Stock
10 mg$43In Stock
25 mg$77In Stock
50 mg$128In Stock
100 mg$193In Stock
200 mg$287In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Product Introduction

Bioactivity
Description
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
Targets&IC50
DNV:>5 μM , Influenza virus:2 μM
In vitro
KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
Alias3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene
Chemical Properties
Molecular Weight395.22
FormulaC16H11BrO5S
Cas No.610753-87-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 32 mg/mL (80.97 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5302 mL12.6512 mL25.3024 mL126.5118 mL
5 mM0.5060 mL2.5302 mL5.0605 mL25.3024 mL
10 mM0.2530 mL1.2651 mL2.5302 mL12.6512 mL
20 mM0.1265 mL0.6326 mL1.2651 mL6.3256 mL
50 mM0.0506 mL0.2530 mL0.5060 mL2.5302 mL

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