keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 247.00 | |
5 mg | In stock | $ 497.00 | |
10 mg | In stock | $ 723.00 | |
25 mg | In stock | $ 1,130.00 | |
50 mg | In stock | $ 1,520.00 | |
100 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 547.00 |
Description | SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses. |
Targets&IC50 | MARV:47.72 μM, EBOV:29.97 μM |
In vitro | SP187 (UV-4) is evaluated in vitro for its antiviral efficacy against EBOV and MARV using a yield-plaque assay format. SP187 demonstrates antiviral activity with IC50 values of 29.97 μM and 47.72 μM against EBOV and MARV, respectively.[1] |
In vivo | In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar-treated mice as compared to the vehicle control.[1] |
Synonyms | UV4, MON-DNJ |
Molecular Weight | 319.44 |
Formula | C16H33NO5 |
CAS No. | 615253-61-7 |
keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 63.89 mg/mL (200 mM)
You can also refer to dose conversion for different animals. More
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SP187 615253-61-7 Microbiology/Virology Others Virus Protease Influenza Virus UV-4 SP 187 MON-DNJ UV 4 SP-187 UV4 MON-DNJ inhibitor inhibit