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Search Results for " dlk "

Targets

6

Compounds

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11056 DLK-IN-1 DNA Alkylation
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days o...
T3707 GNE-3511 GNE3511 DNA Alkylation , MAPK
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T6057 URMC-099 ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T73457 DN-1289 DNA Alkylation
DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK).DN-1289 signif...
T11440 GNE-8505 DNA Alkylation
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
T79303 IACS-52825
IACS-52825 is a potent, selective DLK inhibitor, exhibiting a dissociation constant (Kd) of 1.3 nM, and is valuable for researching chemotherapy-induced peripheral neuropathy (CIPN) [1].

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00942 DLK1 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neu...
TMPK-01274 DLK1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neu...
TMPK-00921 DLK1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neu...
TMPK-00922 DLK1 Protein, Human, Recombinant (aa 24-303, His) Human HEK293 Cells
paternally inherited genetic defects of DLK1 were identified in four families with nonsyndromic CPP and a metabolic phenotype. DLK1 encodes a transmembrane protein that is important for adipose tissue homeostasis and neu...
TMPJ-00509 DLK1 Protein, Human, Recombinant (His) Human HEK293 Cells
Protein Delta Homolog 1 (DLK-1) is a transmembrane protein which contains a signal peptide, an extracellular domain with six tandem epidermai growth factor (EGF)-like domains, a single pass transmembrane domain, and a sh...
TMPY-04385 ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP ...
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