Search Result

Search Results for " cd40l "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11096	DRI-C21045		NF-κB
	Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L...		NF-κB
T76830	Teneliximab	Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819	TNF
	Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD...		TNF
T7649	Tyrphostin A1	AG9,Tyrphostin 1	EGFR , Interleukin
	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .		EGFR , Interleukin
T79193	DRI-C21041
	DRI-C21041 is a potent inhibitor of the CD40/CD40L interaction, demonstrating an inhibitory concentration 50 (IC50) value of 0.31 μM. It effectively suppresses the immune response triggered by alloantigen [1].
T73866	BIO8898
	BIO8898, a potent inhibitor of the CD40-CD154 interaction, effectively prevents soluble CD40L from binding to CD40-Ig, demonstrating an inhibitory concentration (IC 50) value of 25 µM. Additionally, BIO8898 suppresses CD...
T81022	Tegoprubart
	Tegoprubart is a monoclonal antibody targeting CD40 ligand (CD40L), which plays a critical role in costimulation. By inhibiting CD40L, it diminishes both cellular and antibody-mediated immune responses, fostering a more ...
T76834	Toralizumab
	Toralizumab (IDEC-131), a humanized monoclonal antibody (mAb) directed against CD40L (CD154), consists of human gamma 1 heavy chains and human kappa light chains. Specifically targeting CD40L on T cells, it inhibits CD40...
T76825	Ruplizumab
	Ruplizumab (BG 9588), a humanized monoclonal IgG1κ antibody targeting CD40L (TNF Receptor), holds promise for research in systemic lupus erythematosus disease [1].
T82858	Bleselumab	ASKP 1240,Anti-Human CD40 Recombinant Antibody
	Bleselumab (ASKP 1240), a human anti-CD40 monoclonal antibody (mAb), exhibits high-affinity binding to CD40 (Kd: 0.24 nM) and hinders immune responses by impeding the CD40-CD40L interaction, thereby preventing organ tran...
T77013	Frexalimab
	Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].
T77061	Letolizumab
	Letolizumab (BMS-986004), a monoclonal antibody directed at CD40L, is engineered to express a mutant IgG1 devoid of effector functions, such as Fc binding and complement fixation. It effectively reduces rejection and thr...
T78198	DRI-C21041 (DIEA)
	DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM. It effectively suppresses the immune response triggered by alloantigen [1].
T76729	Lucatumumab
	Lucatumumab (HCD122), a fully human anti-CD40 antagonist monoclonal antibody, effectively inhibits CD40/CD40L-mediated signaling and promotes antibody-dependent cell-mediated cytotoxicity (ADCC) for tumor cell clearance....
T79194	DRI-C25441
	DRI-C25441 is a potent inhibitor of the CD40-CD40L interaction, exhibiting an IC50 value of 0.36 μM, and is capable of suppressing the immune response triggered by alloantigen [1].

Compounds

Synonym: Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819

Target: TNF

Tyrphostin A1

T7649

Synonym: AG9,Tyrphostin 1

Target: EGFR, Interleukin

Synonym: ASKP 1240,Anti-Human CD40 Recombinant Antibody

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02439	CD40L Protein, Rhesus macaque, Recombinant (His)	Rhesus	E. coli
	CD40L Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P63304.
TMPY-02022	CD40 Ligand Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965.
TMPY-01758	CD40 Ligand Protein, Human, Recombinant (His)	Human	E. coli
	CD40 Ligand Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P29965.
TMPY-05646	CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.7 kDa and the accession number is P29965.
TMPK-00170	CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated	Human	HEK293 Cells
	CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstr...
TMPY-02793	CD40 Ligand Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CD40 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P27548.
TMPK-00860	CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)	Mouse	HEK293 Cells
	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w...
TMPK-00154	CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated	Human	HEK293 Cells
	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w...
TMPK-01398	CD40 Ligand Trimer Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w...
TMPJ-00634	CD40 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accession number is G7PG38.
TMPJ-01420	CD40 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	CD40 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 48-70 KDa and the accession number is XP_005569275.1.
TMPY-06687	CD40 Ligand Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD40 Ligand Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.37 kDa and the accession number is P27548.
TMPJ-00152	CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-6xHis-Avi tag. The predicted molecular weight is 23-28 KDa and the accession number is P29965.
TMPJ-00153	CD40 Ligand Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	CD40 Ligand Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 19-24 KDa and the accession number is P29965.
TMPJ-00151	CD40 Ligand Protein, Human, Recombinant	Human	E. coli
	CD40 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is P29965.
TMPJ-00150	CD40 Ligand Protein, Human, Recombinant (Mammalian)	Human	HEK293 Cells
	CD40 Ligand Protein, Human, Recombinant (Mammalian) is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-18 KDa and the accession number is P29965.