copd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1532	Pidotimod		Others , Antibacterial
	Pidotimod is a synthetic dipeptide with immunomodulatory properties.		Others , Antibacterial
T2320	Indacaterol		Adrenergic Receptor
	Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.		Adrenergic Receptor
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T9448	IL-17A inhibitor 1		IL Receptor
	IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM.		IL Receptor
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
TN1355	Acanthoside B		Immunology/Inflammation related
	Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.		Immunology/Inflammation related
T15430	GSK2256294A	GSK 2256294	Others , Epoxide Hydrolase
	GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.		Others , Epoxide Hydrolase
T0480	Doxofylline	Doxophylline	PDE , Adenosine Receptor
	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s...		PDE , Adenosine Receptor
T30258	AZD-4818	CCR1 antagonist	CCR
	AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.		CCR
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T22245	Arformoterol Tartrate	(R,R)-Formoterol tartrate	Adrenergic Receptor
	Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity[2].		Adrenergic Receptor
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T0794	Mepenzolate Bromide	Colibantil,Cantil,Cantilaque	AChR
	Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.		AChR
T1239	Indacaterol maleate	QAB149	Adrenergic Receptor
	Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.		Adrenergic Receptor
T5159	Olodaterol hydrochloride	BI-1744 HCl,BI 1744 hydrochloride	Adrenergic Receptor
	Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors...		Adrenergic Receptor
T34387	Ronomilast	ELB353,ELB 353,ELB-353,Elbimilast
	Ronomilast(Elbimilast, ELB 353) is a PDE4 inhibitor for chronic inflammatory disease. Ronomilast is developed to treat chronic obstructive pulmonary disease (COPD).
T33386	Milveterol HCl	Milveterol,GSK-159797,GSK 159797,GSK159797	Adrenergic Receptor
	Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD).		Adrenergic Receptor
T31207	GSK233705	Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B	AChR
	GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans.		AChR
T30232	AWD 12-281	GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470	PDE
	AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory and bronchodilator activity used in the study of chronic obstructive pulmonary disease (COPD).		PDE
T83168	Aderamastat	FP-025	MMP
	Aderamastat (FP-025) is an orally active inhibitor of matrix metalloproteinase 12 (MMP-12), utilized in the research of conditions such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis [1].		MMP