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Doxofylline

Catalog No. T0480 CAS 69975-86-6

Synonyms: Doxophylline

Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.

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Doxofylline, CAS 69975-86-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.
In vitro	At an effective therapeutic dose, Doxofylline exhibits a less pronounced cardiac stimulant effect compared to theophylline. As a result, Doxofylline does not significantly increase heart rate, nor does it induce arrhythmias. Administration of 30 mg/kg of Doxofylline results in an increase of 13 beats/min in the heart rate of anesthetized cats.
In vivo	Doxofylline exhibits the activity of a phosphodiesterase (PDE) inhibitor and enhances the levels of cyclic adenosine monophosphate (cAMP), thus it is utilized in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Compared to theophylline, doxofylline significantly reduces the affinity for adenosine A1 and A2 receptors, which may contribute to its improved safety profile. Additionally, doxofylline does not interfere with calcium ion influx nor antagonize calcium channel blockers. In terms of inhibitory potency, the half-maximal effective concentration (EC50) of doxofylline against adenosine-induced tracheal smooth muscle relaxation is 15-fold higher than that of aminophylline, and it also displays a 15-fold higher EC50 in reducing the negative inotropic effect of adenosine on guinea pig atria than aminophylline.
Source	Natural Products > Theaceae > Camellia

Synonyms	Doxophylline
Molecular Weight	266.25
Formula	C11H14N4O4
CAS No.	69975-86-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL (184 mM)

H2O: 22 mg/mL (82.6 mM)

Ethanol: 2 mg/mL (7.51 mM)

References and Literature

1. Shukla D, et al. Expert Opin Pharmacother, 2009, 10(14), 2343-2356. 2. Dini FL, et al. Curr Med Res Opin, 2001, 16(4), 258-268.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library GPCR Compound Library Anti-Tumor Natural Product Library Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Keywords

Doxofylline 69975-86-6 GPCR/G Protein Metabolism Neuroscience Adenosine Receptor PDE COPD asthma inhibit Doxophylline Reactive Oxygen Species bronchospasm 16HBE cells Inhibitor BM cells P1 receptor Phosphodiesterase (PDE) bronchitis inhibitor

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