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AZD-4818

Catalog No. T30258 CAS 1003566-93-5

Synonyms: AZD4818, CCR1 antagonist, AZD 4818

AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.

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AZD-4818, CAS 1003566-93-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

AZD-4818 is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.

Synonyms	AZD4818, CCR1 antagonist, AZD 4818
Molecular Weight	567.46
Formula	C27H32Cl2N2O7
CAS No.	1003566-93-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gilchrist A, Gauntner TD, Fazzini A, Alley KM, Pyen DS, Ahn J, Ha SJ, Willett A, Sansom SE, Yarfi JL, Bachovchin KA, Mazzoni MR, Merritt JR. Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays. Br J Pharmacol. 2014 Nov;171(22):5127-38. doi: 10.1111/bph.12835. PubMed PMID: 24990525; PubMed Central PMCID: PMC4253460. 2. Olsson B, Borgström L, Lundbäck H, Svensson M. Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation products. J Aerosol Med Pulm Drug Deliv. 2013 Dec;26(6):355-69. doi: 10.1089/jamp.2012.0986. Epub 2013 Feb 19. PubMed PMID: 23421897. 3. Gladue RP, Brown MF, Zwillich SH. CCR1 antagonists: what have we learned from clinical trials. Curr Top Med Chem. 2010;10(13):1268-77. Review. PubMed PMID: 20536425. 4. Kerstjens HA, Bjermer L, Eriksson L, Dahlström K, Vestbo J. Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients. Respir Med. 2010 Sep;104(9):1297-303. doi: 10.1016/j.rmed.2010.04.010. Epub 2010 May 13. PubMed PMID: 20466530.

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Keywords

AZD-4818 1003566-93-5 免疫与炎症微生物学 CCR chemokine COPD AZD4818 CCR1 inhibit Inhibitor CCR1 antagonist AZD 4818 chronic obstructive pulmonary disease CC chemokine receptor inhibitor

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