bxpc-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6347	Ki16198		LPA Receptor , LPL Receptor
	Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ...		LPA Receptor , LPL Receptor
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.		Microtubule Associated
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol	BCL , NF-κB , STAT
	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.		BCL , NF-κB , STAT
T4964	Steviolbioside	CCRIS-6025	Others
	Steviolbioside (CCRIS-6025) is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside(CC...		Others
T4449	LB100	LB-100,LB 100	Phosphatase
	LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.		Phosphatase
T0251	Gemcitabine	NSC 613327,LY188011	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy
	Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
T62890	OXPHOS-IN-1
	OXPHOS-IN-1 (compound 2) is an inhibitor of oxidative phosphorylation (OXPHOS) and inhibits the growth of MIA PaCa-2 cells (IC50: 2.34 μM) and BxPC-3 cells (IC50: 13.82 μM).
T36703	CAY10760
	CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing Bx...
T72569	Cathepsin L/S-IN-1
	Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv...
T62448	Microtubule inhibitor 6
	Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r...
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H46...
T37983	GM 1489
	GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induc...
T79783	NSC 48160		Apoptosis
	NSC 48160, a chemical compound, exhibits inhibitory effects on pancreatic cancer cell proliferation, with half-maximal inhibitory concentrations (IC50s) of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. It also promotes apo...		Apoptosis
T62642	Microtubule inhibitor 4
	Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity.
T36514	QD-394
	QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to...
T6069	Gemcitabine hydrochloride	Gemcitabine HCl,Gemzar,LY188011,LY 188011 hydrochloride	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy
	Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy a...
T15949	Mahanimbine		AChE
	Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cel...		AChE