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Mahanimbine

Catalog No. T15949   CAS 21104-28-9

Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats.

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Mahanimbine Chemical Structure
Mahanimbine, CAS 21104-28-9
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats.
Targets&IC50 S. aureus:50 µg/ml(MIC100), BxPC-3(cells):16 µM, Capan-2(cells):3.5 µM, SW1190(cells):3.5 µM, CFPAC-1(cells):64 µM, HPAF-II(cells):32 µM
In vitro Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).[2]
It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.[3]
In vivo Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin-responsive genes in the liver and adipose tissue. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine (2-4 mg/kg ; p.o. ; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).[1]
Molecular Weight 331.45
Formula C23H25NO
CAS No. 21104-28-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Jagtap S, et al. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations. Biofactors. 2017 ; 43(2):220-231. 2. Pei C, et al. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Med Sci Monit. 2018 ; 24:6975-6983. 3. Birari R, et al. Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia. 2010 ; 81(8):1129-1133. 4. Ramsewak RS, et al. Biologically active carbazole alkaloids from Murraya koenigii. J Agric Food Chem. 1999 ; 47(2):444-447.

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