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20

Compounds

Cat No. Product Name Synonyms Targets
T26559 ACT-462206 OX Receptor
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
T10242 ACT-389949 Others
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of...
T14119 ACT-678689 Compound Example 1.53.4 Hydroxylase
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
T26557 ACT-209905 ACT 209905,ACT209905
ACT-209905 is an agonist of S1P1 receptor.
T9149 2BAct 2B-Act,2B Act PERK
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
T14924 Cenerimod ACT-334441 S1P Receptor
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm...
T3258 Ponesimod ACT-128800 S1P Receptor , LPL Receptor
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
T4020 Cadazolid ACT-179811 Antibacterial , Antibiotic
Cadazolid (ACT-179811) is an oxazolidinone-type antibiotic, with activity against gram-positive bacteria, including Clostridium difficile.
T2058 Palosuran ACT-058362 GPR
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor.
T2561 Macitentan ACT-064992 Apoptosis , Endothelin Receptor
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T35623 ACT-373898
ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1 1.Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan...
T40542 Sinbaglustat ACT-519276,Sinbaglustat,OGT2378 Transferase
Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain...
T7817 Aprocitentan ACT-132577 Endothelin Receptor
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
T2613 Almorexant ACT 078573 OX Receptor
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T4689 Palosuran hydrochloride 540769-28-6(free base) ACT-058362 hydrochloride GPR
Palosuran hydrochloride 540769-28-6(free base)(ACT-058362 hydrochloride) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.
T14120 ACT-709478 Others
ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1].
T70475 ACT-280778
ACT-280778 is a potent L/T calcium channel blocker.
T70616 ACT-672125
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672...
T3216 Selexipag NS-304,ACT-293987,Uptravi Others , Prostaglandin Receptor
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).
T3S2007 MRE-269 MRE 269,ACT-333679,MRE269 Prostaglandin Receptor
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo...
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TargetMol