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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T26559 | ACT-462206 | OX Receptor | |
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. | |||
T10242 | ACT-389949 | Others | |
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of... | |||
T14119 | ACT-678689 | Compound Example 1.53.4 | Hydroxylase |
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. | |||
T26557 | ACT-209905 | ACT 209905,ACT209905 | |
ACT-209905 is an agonist of S1P1 receptor. | |||
T9149 | 2BAct | 2B-Act,2B Act | PERK |
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response | |||
T14924 | Cenerimod | ACT-334441 | S1P Receptor |
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm... | |||
T3258 | Ponesimod | ACT-128800 | S1P Receptor , LPL Receptor |
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. | |||
T4020 | Cadazolid | ACT-179811 | Antibacterial , Antibiotic |
Cadazolid (ACT-179811) is an oxazolidinone-type antibiotic, with activity against gram-positive bacteria, including Clostridium difficile. | |||
T2058 | Palosuran | ACT-058362 | GPR |
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor. | |||
T2561 | Macitentan | ACT-064992 | Apoptosis , Endothelin Receptor |
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T35623 | ACT-373898 | ||
ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1 1.Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan... | |||
T40542 | Sinbaglustat | ACT-519276,Sinbaglustat,OGT2378 | Transferase |
Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain... | |||
T7817 | Aprocitentan | ACT-132577 | Endothelin Receptor |
Aprocitentan (ACT-132577) is ETA and ETB antagonist . | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T4689 | Palosuran hydrochloride 540769-28-6(free base) | ACT-058362 hydrochloride | GPR |
Palosuran hydrochloride 540769-28-6(free base)(ACT-058362 hydrochloride) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM. | |||
T14120 | ACT-709478 | Others | |
ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1]. | |||
T70475 | ACT-280778 | ||
ACT-280778 is a potent L/T calcium channel blocker. | |||
T70616 | ACT-672125 | ||
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672... | |||
T3216 | Selexipag | NS-304,ACT-293987,Uptravi | Others , Prostaglandin Receptor |
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T3S2007 | MRE-269 | MRE 269,ACT-333679,MRE269 | Prostaglandin Receptor |
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo... |