Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 89.00 | |
5 mg | 5 days | $ 178.00 |
Description | ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1]. |
Targets&IC50 | Cav 3.1:6.4 nM, Cav 3.2:18 nM, Cav 3.3:7.5 nM, Cav 1.2:2410 nM |
In vitro | ACT-709478 (Compound 66b) blocks Cav3.1, Cav3.2, Cav3.3, Cav1.2 with IC50s of 6.4, 18, 7.5 and 2410 nM, respectively. ACT-709478 blocks recombinant channel hCav3.3 potently with marked voltage-dependency (Kr≈1500 nM and Ki≈20 nM). ACT-709478 blocks currents through hKv11.1-hERG channels with an IC50 of 5.5 μM[1]. ACT-709478 also inhibits P450 enzymes with IC50s of 14, 15, 22, 25, 51 and 52 μM for CYP2C8,CYP2D6 CYP2C9, CYP2C19, CYP3A4, and CYP2B6, respectively[1]. |
In vivo | ACT-709478 ( 100, 300 mg/kg, p.o., 12 hours) can decreas the cumulative duration of absence-like seizures in mice[1]. |
Molecular Weight | 425.41 |
Formula | C22H18F3N5O |
CAS No. | 1838651-58-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (293.83 mM)
You can also refer to dose conversion for different animals. More
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ACT-709478 1838651-58-3 Others ACT 709478 ACT709478 inhibitor inhibit