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2BAct

Catalog No. T9149 CAS 2143542-28-1

Synonyms: 2B-Act, 2B Act

2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response

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2BAct, CAS 2143542-28-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
Targets&IC50	eIF2B:33 nM (EC50)

Synonyms	2B-Act, 2B Act
Molecular Weight	440.81
Formula	C19H16ClF3N4O3
CAS No.	2143542-28-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 240 mg/mL (544.46 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019 Jan 9;8. pii. e42940.

Related Products

Related compounds with same targets

Rocaglamide 2BAct BTdCPU ISRIB (trans-isomer) SHP099 Briciclib 4EGI-1 GSK2606414

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

2BAct 2143542-28-1 凋亡 PERK permeable primary inhibit 2B-Act Eukaryotic Initiation Factor (eIF) stress defects response 2B Act fibroblast neurological Inhibitor CNS inhibitor

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