Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 159.00 | |
5 mg | In stock | $ 326.00 | |
10 mg | In stock | $ 501.00 | |
25 mg | In stock | $ 817.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,530.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 511.00 |
Description | ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. |
Targets&IC50 | TPH:8 nM |
In vitro | TPH consists of two isoforms, TPH1 and TPH2. TPH1 is primarily found in peripheral tissues, especially the enterochromaffin cells (EC) in the gut, and is vital for the synthesis of 5HT, which is stored in the circulating blood platelets[1]. Conversely, TPH2 is predominantly expressed in neuronal cell types within the central nervous system (CNS). |
Synonyms | Compound Example 1.53.4 |
Molecular Weight | 565.04 |
Formula | C23H22ClFN6O4S2 |
CAS No. | 1783256-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (212.37 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ACT-678689 1783256-96-1 Metabolism Hydroxylase Tryptophan Hydroxylase Inhibitor ACT 678689 ACT678689 Compound Example 1.53.4 inhibit inhibitor