6-ohda — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T16605	Propargyl-PEG3-acid		PROTAC Linker
	Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].		PROTAC Linker
T6S1587	Notoginsenoside R2	20(S)-Notoginsenoside R2,Ginsenoside Ng-R2	Others , Nrf2
	Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.		Others , Nrf2
T73331	GSK3-IN-3		Mitophagy , GSK-3
	GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective...		Mitophagy , GSK-3
T3755	Pinostilbene		Others
	Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.		Others
T3106	C-DIM12		Apoptosis , Others
	C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure ...		Apoptosis , Others
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T38034	MAO-IN-M30 dihydrochloride	M 30 dihydrochloride	Monoamine Oxidase
	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant...		Monoamine Oxidase
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T4S1962	Beta-Asarone	Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB , JNK
	1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...		NF-κB , JNK
T28793	SKF-80723 HBr	SKF80723 Hydrobromide,SKF 80723 HBr,SKF-80723 Hydrobromide,SKF 80723 Hydrobromide
	SKF-80723 HBr is a D1 receptor agonist. SKF-80723 HBr strongly potentiated the contralateral circling induced by quinpirole in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle.
T3490	Alpha-(3,4-Dihydroxyphenyl)lactic acid		Antioxidant
	Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.		Antioxidant
T82058	Inubritannolide A
	Inubritannolide A exhibits moderate to robust neuroprotective effects across various neuronal cell types against inducers such as H2O2, 6-hydroxydopamine (6-OHDA), and lipopolysaccharide (LPS).
T82042	Isoasiaticoside
	Isoasiaticoside, a pentacyclic triterpene saponin derived from Centella asiatica, exhibits potential neuroprotective effects in the 6-OHDA-induced PC12 cell model [1].
T27282	Erucin	AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-...
T37605	D-DOPA
	D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, i...