Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].
Pack Size | Availability | Price/USD | Quantity |
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50 mg | In stock | $ 42.00 |
Description | Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1]. |
In vitro | ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E6 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 216.23 |
Formula | C10H16O5 |
CAS No. | 1347760-82-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Propargyl-PEG3-acid 1347760-82-0 PROTAC PROTAC Linker Propargyl PEG3 acid PROTAC Linkers PropargylPEG3acid Inhibitor ADC Linkers inhibit Antibody-drug conjugates linkers Propargyl-PEG-3-acid inhibitor