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alpha-(3,4-Dihydroxyphenyl)lactic acid

Catalog No. T3490   CAS 22681-72-7

Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.

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alpha-(3,4-Dihydroxyphenyl)lactic acid Chemical Structure
alpha-(3,4-Dihydroxyphenyl)lactic acid, CAS 22681-72-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.
Kinase Assay The recombinant HCV polymerases used in this study contain the first 570 amino acids of the 591-amino acid native protein sequence, with a six-histidine tag at the N terminus to facilitate purification by affinity chromatography. Briefly, ABT-333 (Dasabuvir) is incubated with 5 to 50 nM polymerase for 15 min at room temperature, follow by the addition of nucleoside triphosphates (NTPs) and [3H]UTP for 3 h at 30°C. After termination of the reaction, the precipitated RNA is captured by filtration through a GF/B filter. The amount of incorporated [3H]UTP is measured by scintillation counting with a Wallac 1450 MicroBeta counter. The percent inhibition is calculated from the initial rates of inhibited reactions relative to that of the uninhibited control reaction. The mean 50% inhibitory concentration (IC50) and the standard error of the mean (SEM) are calculated via nonlinear regression[1].
Molecular Weight 198.17
Formula C9H10O5
CAS No. 22681-72-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: Soluble

TargetMolReferences and Literature

1. Kwon G1, Kim HJ2, Park SJ1,et al.Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice.Life Sci. 2014 Apr 17;101(1-2):73-8. 2. Cui Q1, Chen Y, Zhang M, et al.Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives.Chem Biol Drug Des. 2014 Sep;84(3):282-91. 3. Chong CM1, Zhou ZY, et al.Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish.Neurosci Lett. 2013 May 24;543:121-5.

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Keywords

alpha-(3,4-Dihydroxyphenyl)lactic acid 22681-72-7 oxidation-reduction Antioxidant alpha (3,4 Dihydroxyphenyl)lactic acid α-(3,4-Dihydroxyphenyl)lactic acid alpha(3,4Dihydroxyphenyl)lactic acid a-(3,4-Dihydroxyphenyl)lactic acid inhibitor inhibit

 

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