Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 139.00 | |
50 mg | In stock | $ 222.00 | |
100 mg | In stock | $ 355.00 | |
200 mg | In stock | $ 527.00 | |
500 mg | In stock | $ 842.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. |
In vitro | C-DIM12 induces Nurr1 and DA gene expression in cell lines and primary neurons[3]. C-DIM12 suppresses astrocyte inflammatory signaling in vitro. C-DIM12 inhibits lipopolysaccharide (LPS)–induced expression of NF-κB-regulated genes in BV-2 microglia including nitric oxide synthase (NOS2), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2), and the effects were attenuated by Nurr1-RNA interference. Additionally, C-DIM12 decreased NF-κB activation in NF-κB–GFP (green fluorescent protein) reporter cells and enhanced nuclear translocation of Nurr1 primary microglia. C-DIM12 decreases lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2)[2]. |
In vivo | C-DIM12 has the neuroprotective activity in MPTPp-treated mice[2]. |
Cell Research | NF-κB–GFP HEK cells are exposed to 30 ng/ml of TNFα in the presence of 100 μM C-DIM12 for up to 24 hours. C-DIM12 is efficient at blocking NF-κB–GFP expression in the NF-κB–GFP HEK cells after TNFα treatment, displaying a statistically significant reduction in total GFP fluorescence per cell.(Only for Reference) |
Molecular Weight | 356.85 |
Formula | C23H17ClN2 |
CAS No. | 178946-89-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35.7 mg/mL (100 mM)
Ethanol: 35.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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C-DIM12 178946-89-9 Apoptosis Others inhibit Inhibitor C-DIM-12 CDIM12 C DIM12 inhibitor