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Transforming Growth Factor-β family, TGF-βs

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.

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Species
Canine (5)
Cynomolgus (6)
Human (43)
Mouse (26)
Rat (13)
Rhesus (2)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (12)
HEK293 Cells (56)
P. pastoris (Yeast) (1)
Tag
C-6xHis (3)
C-His (14)
C-hFc (1)
C-mFc-Avi (2)
GST (1)
His (1)
N-6xHis (4)
N-6xHis-Avi (1)
N-6xHis-Flag (1)
N-8xHis-Avi (3)
N-8xHis-Flag (1)
N-Avi (3)
N-His (8)
N-His-Avi (1)
N-His-GST (2)
N-hFc (15)
Tag Free (15)
Cat No. product name / Synonyms Species Expression System
TMPJ-00100 Artemin Protein, Human, Recombinant
Artemin Protein, Human, Recombinant
Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
TMPJ-00238 Lefty-A Protein, Human, Recombinant (His)
Lefty-A Protein, Human, Recombinant (His)
Human HEK293 Cells
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
Human HEK293 Cells
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
TMPJ-00259 TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
Human HEK293 Cells
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and...
TMPJ-00260 Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
TMPJ-00271 SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD3 Protein, Human, Recombinant (His & Flag)
Human E. coli
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocati...
TMPJ-00622 Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 11 and 35-45 ...
TMPJ-00663 GDF-8 Protein, Human/Mouse/Rat, Recombinant
GDF-8 Protein, Human/Mouse/Rat, Recombinant
Human,Mouse,Rat HEK293 Cells
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is c...
TMPJ-00713 GDF-11 Protein, Human, Recombinant
GDF-11 Protein, Human, Recombinant
Human HEK293 Cells
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-poster...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant
TGF beta 1 Protein, Mouse/Rat, Recombinant
Mouse,Rat HEK293 Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
TMPJ-00772 Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Mouse HEK293 Cells
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
TMPJ-00966 GDF-5 Protein, Human, Recombinant
GDF-5 Protein, Human, Recombinant
Human E. coli
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the ...
TMPJ-01015 INHBC Protein, Human, Recombinant (C-His)
INHBC Protein, Human, Recombinant (C-His)
Human HEK293 Cells
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through associatio...
TMPJ-01016 INHBC Protein, Human, Recombinant (N-His)
INHBC Protein, Human, Recombinant (N-His)
Human E. coli
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ ...
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His)
SMAD4 Protein, Human, Recombinant (His)
Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD ho...
TMPJ-01226 Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
Human,Mouse,Rat HEK293 Cells
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-60 KDa and the acce...
TMPJ-01227 Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
Human,Mouse,Rat HEK293 Cells
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-28 KDa and the...
TMPJ-01228 Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
Human,Mouse,Rat HEK293 Cells
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the...
Artemin Protein, Human, Recombinant
TMPJ-00100
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
Lefty-A Protein, Human, Recombinant (His)
TMPJ-00238
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated...
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00250
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and...
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00259
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and...
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00260
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
SMAD3 Protein, Human, Recombinant (His & Flag)
TMPJ-00271
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocati...
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00622
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 11 and 35-45 ...
GDF-8 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00663
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is c...
GDF-11 Protein, Human, Recombinant
TMPJ-00713
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-poster...
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPJ-00772
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weig...
GDF-5 Protein, Human, Recombinant
TMPJ-00966
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the ...
INHBC Protein, Human, Recombinant (C-His)
TMPJ-01015
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through associatio...
INHBC Protein, Human, Recombinant (N-His)
TMPJ-01016
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ ...
SMAD4 Protein, Human, Recombinant (His)
TMPJ-01108
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD ho...
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc)
TMPJ-01226
Irisin Protein, Human/Mouse/Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-60 KDa and the acce...
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His)
TMPJ-01227
Irisin Protein, Human/Mouse/Rat, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-28 KDa and the...
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His)
TMPJ-01228
Irisin Protein, Human/Mouse/Rat, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18-28 KDa and the...
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