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Transforming Growth Factor-β family, TGF-βs

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.

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Species
Canine (5)
Cynomolgus (6)
Human (43)
Mouse (26)
Rat (13)
Rhesus (2)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (12)
HEK293 Cells (56)
P. pastoris (Yeast) (1)
Tag
C-6xHis (3)
C-His (14)
C-hFc (1)
C-mFc-Avi (2)
GST (1)
His (1)
N-6xHis (4)
N-6xHis-Avi (1)
N-6xHis-Flag (1)
N-8xHis-Avi (3)
N-8xHis-Flag (1)
N-Avi (3)
N-His (8)
N-His-Avi (1)
N-His-GST (2)
N-hFc (15)
Tag Free (15)
Cat No. product name / Synonyms Species Expression System
TMPY-03945 Latent TGF beta 1 Protein, Rat, Recombinant (His)
Latent TGF beta 1 Protein, Rat, Recombinant (His)
Rat HEK293 Cells
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accessi...
TMPY-00608 TGF beta 1 Protein, Rat/Mouse, Recombinant
TGF beta 1 Protein, Rat/Mouse, Recombinant
Mouse,Rat HEK293 Cells
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
TMPY-04211 Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa.
TMPY-02638 TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
Human,Rhesus,Cynomolgus,Canine CHO Cells
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession...
TMPY-00500 Latent TGF beta 1 Protein, Mouse, Recombinant (His)
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the acces...
TMPY-04727 GDF-15 Protein, Human, Recombinant (His)
GDF-15 Protein, Human, Recombinant (His)
Human P. pastoris (Yeast)
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
TMPY-01073 GDF-15 Protein, Human, Recombinant (hFc)
GDF-15 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number...
TMPY-06247 TGF beta 3 Protein, Human, Recombinant (hFc)
TGF beta 3 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession nu...
TMPJ-00249 TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
Human HEK293 Cells
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and ...
TMPJ-00254 TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Human,Mouse,Rat HEK293 Cells
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted a...
TMPJ-00258 TGF beta 2 Protein, Human, Recombinant
TGF beta 2 Protein, Human, Recombinant
Human HEK293 Cells
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular fun...
TMPJ-00261 TGF beta 2 Protein, Mouse/Rat, Recombinant
TGF beta 2 Protein, Mouse/Rat, Recombinant
Mouse,Rat HEK293 Cells
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deleti...
TMPJ-01471 Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Human/Mouse/Rat HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfami...
TMPY-01133 Latent TGF beta 1 Protein, Human, Recombinant (His)
Latent TGF beta 1 Protein, Human, Recombinant (His)
Human HEK293 Cells
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the acces...
TMPY-02792 GDNF Protein, Human, Recombinant (HEK293)
GDNF Protein, Human, Recombinant (HEK293)
Human HEK293 Cells
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2...
Latent TGF beta 1 Protein, Rat, Recombinant (His)
TMPY-03945
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accessi...
TGF beta 1 Protein, Rat/Mouse, Recombinant
TMPY-00608
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
TMPY-04211
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa.
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
TMPY-02638
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession...
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
TMPY-00500
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the acces...
GDF-15 Protein, Human, Recombinant (His)
TMPY-04727
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
GDF-15 Protein, Human, Recombinant (hFc)
TMPY-01073
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number...
TGF beta 3 Protein, Human, Recombinant (hFc)
TMPY-06247
TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession nu...
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00249
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and ...
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
TMPJ-00254
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted a...
TGF beta 2 Protein, Human, Recombinant
TMPJ-00258
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular fun...
TGF beta 2 Protein, Mouse/Rat, Recombinant
TMPJ-00261
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deleti...
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
TMPJ-01471
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfami...
Latent TGF beta 1 Protein, Human, Recombinant (His)
TMPY-01133
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the acces...
GDNF Protein, Human, Recombinant (HEK293)
TMPY-02792
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2...
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TargetMol