Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPJ-01290 | Neurturin Protein, Human, Recombinant
Neurturin Protein, Human, Recombinant
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Human | E. coli |
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is... | |||
TMPJ-01414 | GDF-15 Protein, Mouse, Recombinant (His & Flag)
GDF-15 Protein, Mouse, Recombinant (His & Flag)
|
Mouse | HEK293 Cells |
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be ... | |||
TMPK-00109 | Artemin Protein, Human, Recombinant (hFc)
Artemin Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ... | |||
TMPK-00196 | GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | E. coli |
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i... | |||
TMPK-00197 | GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
|
Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-00198 | GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
|
Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-00258 | Latent TGF beta 3 Protein, Human, Recombinant (His)
Latent TGF beta 3 Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc... | |||
TMPK-00259 | Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
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Human | HEK293 Cells |
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc... | |||
TMPK-00328 | TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
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Human | HEK293 Cells |
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t... | |||
TMPK-00329 | TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
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Human | HEK293 Cells |
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t... | |||
TMPK-00569 | GDF-15 Protein, Canine, Recombinant (His)
GDF-15 Protein, Canine, Recombinant (His)
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Canine | E. coli |
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i... | |||
TMPK-00663 | GDF-15 Protein, Cynomolgus, Recombinant (hFc)
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-00664 | GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
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Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-00665 | GDF-15 Protein, Cynomolgus, Recombinant (His)
GDF-15 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-01243 | GDF-15 Protein, Rat, Recombinant (His)
GDF-15 Protein, Rat, Recombinant (His)
|
Rat | E. coli |
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i... | |||
TMPK-01244 | GDF-15 Protein, Mouse, Recombinant (hFc)
GDF-15 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-01245 | GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
|
Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPK-01246 | GDF-15 Protein, Mouse, Recombinant (His)
GDF-15 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter... | |||
TMPY-00229 | Latent TGF beta 1 Protein, Canine, Recombinant (His)
Latent TGF beta 1 Protein, Canine, Recombinant (His)
|
Canine | HEK293 Cells |
Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa. | |||
TMPY-00231 | TGF beta 2 Protein, Canine, Recombinant (His)
TGF beta 2 Protein, Canine, Recombinant (His)
|
Canine | HEK293 Cells |
TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num... |