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Transforming Growth Factor-β family, TGF-βs

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.

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Species
Canine (5)
Cynomolgus (6)
Human (43)
Mouse (26)
Rat (13)
Rhesus (2)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (12)
HEK293 Cells (56)
P. pastoris (Yeast) (1)
Tag
C-6xHis (3)
C-His (14)
C-hFc (1)
C-mFc-Avi (2)
GST (1)
His (1)
N-6xHis (4)
N-6xHis-Avi (1)
N-6xHis-Flag (1)
N-8xHis-Avi (3)
N-8xHis-Flag (1)
N-Avi (3)
N-His (8)
N-His-Avi (1)
N-His-GST (2)
N-hFc (15)
Tag Free (15)
Cat No. product name / Synonyms Species Expression System
TMPJ-01290 Neurturin Protein, Human, Recombinant
Neurturin Protein, Human, Recombinant
Human E. coli
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is...
TMPJ-01414 GDF-15 Protein, Mouse, Recombinant (His & Flag)
GDF-15 Protein, Mouse, Recombinant (His & Flag)
Mouse HEK293 Cells
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be ...
TMPK-00109 Artemin Protein, Human, Recombinant (hFc)
Artemin Protein, Human, Recombinant (hFc)
Human HEK293 Cells
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
TMPK-00196 GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
Human E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
TMPK-00197 GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
Human HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-00198 GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
Human HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-00258 Latent TGF beta 3 Protein, Human, Recombinant (His)
Latent TGF beta 3 Protein, Human, Recombinant (His)
Human HEK293 Cells
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc...
TMPK-00259 Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
Human HEK293 Cells
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc...
TMPK-00328 TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
Human HEK293 Cells
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TMPK-00329 TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
Human HEK293 Cells
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TMPK-00569 GDF-15 Protein, Canine, Recombinant (His)
GDF-15 Protein, Canine, Recombinant (His)
Canine E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
TMPK-00663 GDF-15 Protein, Cynomolgus, Recombinant (hFc)
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
Cynomolgus HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-00664 GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
Cynomolgus HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-00665 GDF-15 Protein, Cynomolgus, Recombinant (His)
GDF-15 Protein, Cynomolgus, Recombinant (His)
Cynomolgus E. coli
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-01243 GDF-15 Protein, Rat, Recombinant (His)
GDF-15 Protein, Rat, Recombinant (His)
Rat E. coli
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
TMPK-01244 GDF-15 Protein, Mouse, Recombinant (hFc)
GDF-15 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-01245 GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
Mouse HEK293 Cells
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPK-01246 GDF-15 Protein, Mouse, Recombinant (His)
GDF-15 Protein, Mouse, Recombinant (His)
Mouse E. coli
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
TMPY-00229 Latent TGF beta 1 Protein, Canine, Recombinant (His)
Latent TGF beta 1 Protein, Canine, Recombinant (His)
Canine HEK293 Cells
Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa.
TMPY-00231 TGF beta 2 Protein, Canine, Recombinant (His)
TGF beta 2 Protein, Canine, Recombinant (His)
Canine HEK293 Cells
TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num...
Neurturin Protein, Human, Recombinant
TMPJ-01290
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is...
GDF-15 Protein, Mouse, Recombinant (His & Flag)
TMPJ-01414
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be ...
Artemin Protein, Human, Recombinant (hFc)
TMPK-00109
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00196
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
TMPK-00197
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
TMPK-00198
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
Latent TGF beta 3 Protein, Human, Recombinant (His)
TMPK-00258
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc...
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00259
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, inc...
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TMPK-00328
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TMPK-00329
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from t...
GDF-15 Protein, Canine, Recombinant (His)
TMPK-00569
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
TMPK-00663
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
TMPK-00664
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein, Cynomolgus, Recombinant (His)
TMPK-00665
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein, Rat, Recombinant (His)
TMPK-01243
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, i...
GDF-15 Protein, Mouse, Recombinant (hFc)
TMPK-01244
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
TMPK-01245
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
GDF-15 Protein, Mouse, Recombinant (His)
TMPK-01246
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacter...
Latent TGF beta 1 Protein, Canine, Recombinant (His)
TMPY-00229
Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa.
TGF beta 2 Protein, Canine, Recombinant (His)
TMPY-00231
TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num...
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