Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPY-00413 | Latent TGF beta 2 Protein, Mouse, Recombinant (His)
Latent TGF beta 2 Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession nu... | |||
TMPY-00990 | Lefty-A Protein, Human, Recombinant (hFc)
Lefty-A Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determi... | |||
TMPY-01190 | INHBB Protein, Human, Recombinant (His)
INHBB Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar... | |||
TMPY-01576 | Artemin Protein, Mouse, Recombinant (hFc)
Artemin Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ... | |||
TMPY-01817 | GDF-10 Protein, Mouse, Recombinant (hFc)
GDF-10 Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic p... | |||
TMPY-01846 | Activin A Protein, Mouse, Recombinant (His)
Activin A Protein, Mouse, Recombinant (His)
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Mouse | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar... | |||
TMPY-02911 | GDNF Protein, Rat, Recombinant (His)
GDNF Protein, Rat, Recombinant (His)
|
Rat | Baculovirus Insect Cells |
GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number i... | |||
TMPY-03291 | SMAD2 Protein, Mouse, Recombinant (His & GST)
SMAD2 Protein, Mouse, Recombinant (His & GST)
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Mouse | Baculovirus Insect Cells |
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/T... | |||
TMPY-03292 | SMAD5 Protein, Mouse, Recombinant (His & GST)
SMAD5 Protein, Mouse, Recombinant (His & GST)
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Mouse | Baculovirus Insect Cells |
SMAD5 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.9 kDa and the a... | |||
TMPY-03419 | SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
|
Human,Mouse,Rat | Baculovirus Insect Cells |
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr p... | |||
TMPY-03469 | SMAD5 Protein, Mouse, Recombinant
SMAD5 Protein, Mouse, Recombinant
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Mouse | Baculovirus Insect Cells |
SMAD5 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 52.2 kDa and the accession number is P97454. | |||
TMPY-04534 | GDF-8 Protein, Mouse, Recombinant (hFc)
GDF-8 Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a po... | |||
TMPY-04535 | GDNF Protein, Canine, Recombinant (hFc)
GDNF Protein, Canine, Recombinant (hFc)
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Canine | HEK293 Cells |
GDNF Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is... | |||
TMPY-04577 | TGF beta 2 Protein, Rhesus, Recombinant (His)
TGF beta 2 Protein, Rhesus, Recombinant (His)
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Rhesus | HEK293 Cells |
TGF beta 2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num... | |||
TMPY-05029 | INHBE Protein, Human, Recombinant (hFc)
INHBE Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Th... | |||
TMPY-05313 | Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 Cells |
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa... | |||
TMPY-05314 | TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 Cells |
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and th... | |||
TMPY-05521 | Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
|
Human | HEK293 Cells |
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa... | |||
TMPY-06355 | Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10... | |||
TMPY-06970 | GDNF Protein, Human, Recombinant
GDNF Protein, Human, Recombinant
|
Human | E. coli |
GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1. |