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Transforming Growth Factor-β family, TGF-βs

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed of both type 1 and type 2 receptor subunits. After the binding of TGF-β, the type 2 receptor kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream substrates and regulatory proteins. TGF-β also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. Because of its role in immune and stem cell regulation and differentiation, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.

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Species
Canine (5)
Cynomolgus (6)
Human (43)
Mouse (26)
Rat (13)
Rhesus (2)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (12)
HEK293 Cells (56)
P. pastoris (Yeast) (1)
Tag
C-6xHis (3)
C-His (14)
C-hFc (1)
C-mFc-Avi (2)
GST (1)
His (1)
N-6xHis (4)
N-6xHis-Avi (1)
N-6xHis-Flag (1)
N-8xHis-Avi (3)
N-8xHis-Flag (1)
N-Avi (3)
N-His (8)
N-His-Avi (1)
N-His-GST (2)
N-hFc (15)
Tag Free (15)
Cat No. product name / Synonyms Species Expression System
TMPY-00413 Latent TGF beta 2 Protein, Mouse, Recombinant (His)
Latent TGF beta 2 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession nu...
TMPY-00990 Lefty-A Protein, Human, Recombinant (hFc)
Lefty-A Protein, Human, Recombinant (hFc)
Human HEK293 Cells
left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determi...
TMPY-01190 INHBB Protein, Human, Recombinant (His)
INHBB Protein, Human, Recombinant (His)
Human HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar...
TMPY-01576 Artemin Protein, Mouse, Recombinant (hFc)
Artemin Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
TMPY-01817 GDF-10 Protein, Mouse, Recombinant (hFc)
GDF-10 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic p...
TMPY-01846 Activin A Protein, Mouse, Recombinant (His)
Activin A Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar...
TMPY-02911 GDNF Protein, Rat, Recombinant (His)
GDNF Protein, Rat, Recombinant (His)
Rat Baculovirus Insect Cells
GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number i...
TMPY-03291 SMAD2 Protein, Mouse, Recombinant (His & GST)
SMAD2 Protein, Mouse, Recombinant (His & GST)
Mouse Baculovirus Insect Cells
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/T...
TMPY-03292 SMAD5 Protein, Mouse, Recombinant (His & GST)
SMAD5 Protein, Mouse, Recombinant (His & GST)
Mouse Baculovirus Insect Cells
SMAD5 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.9 kDa and the a...
TMPY-03419 SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
Human,Mouse,Rat Baculovirus Insect Cells
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr p...
TMPY-03469 SMAD5 Protein, Mouse, Recombinant
SMAD5 Protein, Mouse, Recombinant
Mouse Baculovirus Insect Cells
SMAD5 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 52.2 kDa and the accession number is P97454.
TMPY-04534 GDF-8 Protein, Mouse, Recombinant (hFc)
GDF-8 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a po...
TMPY-04535 GDNF Protein, Canine, Recombinant (hFc)
GDNF Protein, Canine, Recombinant (hFc)
Canine HEK293 Cells
GDNF Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is...
TMPY-04577 TGF beta 2 Protein, Rhesus, Recombinant (His)
TGF beta 2 Protein, Rhesus, Recombinant (His)
Rhesus HEK293 Cells
TGF beta 2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num...
TMPY-05029 INHBE Protein, Human, Recombinant (hFc)
INHBE Protein, Human, Recombinant (hFc)
Human HEK293 Cells
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Th...
TMPY-05313 Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
Mouse HEK293 Cells
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa...
TMPY-05314 TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
Mouse HEK293 Cells
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and th...
TMPY-05521 Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
Human HEK293 Cells
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa...
TMPY-06355 Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
Human HEK293 Cells
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10...
TMPY-06970 GDNF Protein, Human, Recombinant
GDNF Protein, Human, Recombinant
Human E. coli
GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
Latent TGF beta 2 Protein, Mouse, Recombinant (His)
TMPY-00413
TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession nu...
Lefty-A Protein, Human, Recombinant (hFc)
TMPY-00990
left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determi...
INHBB Protein, Human, Recombinant (His)
TMPY-01190
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar...
Artemin Protein, Mouse, Recombinant (hFc)
TMPY-01576
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
GDF-10 Protein, Mouse, Recombinant (hFc)
TMPY-01817
BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic p...
Activin A Protein, Mouse, Recombinant (His)
TMPY-01846
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes ar...
GDNF Protein, Rat, Recombinant (His)
TMPY-02911
GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number i...
SMAD2 Protein, Mouse, Recombinant (His & GST)
TMPY-03291
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/T...
SMAD5 Protein, Mouse, Recombinant (His & GST)
TMPY-03292
SMAD5 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.9 kDa and the a...
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
TMPY-03419
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr p...
SMAD5 Protein, Mouse, Recombinant
TMPY-03469
SMAD5 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 52.2 kDa and the accession number is P97454.
GDF-8 Protein, Mouse, Recombinant (hFc)
TMPY-04534
GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a po...
GDNF Protein, Canine, Recombinant (hFc)
TMPY-04535
GDNF Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is...
TGF beta 2 Protein, Rhesus, Recombinant (His)
TMPY-04577
TGF beta 2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession num...
INHBE Protein, Human, Recombinant (hFc)
TMPY-05029
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Th...
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05313
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa...
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05314
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and th...
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
TMPY-05521
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa...
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
TMPY-06355
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10...
GDNF Protein, Human, Recombinant
TMPY-06970
GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
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TargetMol