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Tamoxifen
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Catalog No. T6906Cas No. 10540-29-1
Alias Z-Tamoxifen, trans-Tamoxifen, ICI47699
Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.
Tamoxifen
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Purity: 99.92%
Catalog No. T6906Alias Z-Tamoxifen, trans-Tamoxifen, ICI47699Cas No. 10540-29-1
Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $30 | In Stock | In Stock | |
| 500 mg | $39 | In Stock | In Stock | |
| 1 g | $55 | In Stock | In Stock | |
| 5 g | $128 | - | In Stock | |
| 10 g | $189 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.92%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections. |
| Targets&IC50 | DU-145 cells:10.87 μM, CHO cells:> 100 μM, A431 cells:> 100 μM, A549 cells:1.86 μg/mL, 518A2 cells:7.62 μM, B16 F10 cells:64.87 μM, DLD-1 cells:11.06 μM, A2780 cells:7.77 μM, A2058 cells:12.5 μM (EC50), Astrocytes:> 10 μM, FaDu cells:5.39 μM, A253 cells:8.92 μM |
| In vitro | METHODS: Human breast cancer cells MCF-7 were treated with Tamoxifen (0.25-4 μM) for 24 h. Cell viability was measured using the CCK-8. RESULTS: Tamoxifen significantly inhibited the proliferation of MCF-7 cells in a dose-dependent manner. [1] METHODS: ER-negative breast cancer cells SK-BR3, MDA-MB-453, MDA-MB-468, MDA-MB-231, and HCC-1937 were treated with Tamoxifen (1-10 μM) for 24-36 h, and apoptosis was detected using Flow Cytometry. RESULTS: Tamoxifen induced apoptosis in MDA-MB-231, MDA-MB-468, MDA-MB-453 and SK-BR3 cells in a dose- and time-dependent manner, while no significant apoptotic effect was observed in HCC-1937 cells. [2] |
| In vivo | METHODS: To test the antitumor activity in vivo, Tamoxifen (100 mg/kg) was administered orally to NCr athymic nude mice bearing ER-negative breast cancer tumors MDA-MB-468 or HCC-1937 three times per week for four to five weeks. RESULTS: Tamoxifen significantly inhibited the growth of MDA-MB-468 tumors, whereas the growth of HCC-1937 tumors was not affected. [2] METHODS: To test the effect on mouse behavior, Tamoxifen (75 mg/kg in 10% ethanol+90% sunflower seed oil) was administered intraperitoneally to C57BL/6 mice once a day for seven days. RESULTS: Tamoxifen affects motor activity, socialization, and anxiety in mice. [3] |
| Synonyms | Z-Tamoxifen, trans-Tamoxifen, ICI47699 |
| Molecular Weight | 371.51 |
| Formula | C26H29NO |
| Cas No. | 10540-29-1 |
| Smiles | CC\C(C1=CC=CC=C1)=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1 |
| Relative Density. | 1.042 g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (33.65 mM), Sonication is recommended.  Ethanol: 100 mg/mL (269.17 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | Corn oil: 40 mg/mL (107.67 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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