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Sophoraflavanone G

Catalog No. T5S1000   CAS 97938-30-2
Synonyms: Kushenol F, Vexibinol

Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

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Sophoraflavanone G Chemical Structure
Sophoraflavanone G, CAS 97938-30-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 96.00
10 mg In stock $ 165.00
25 mg In stock $ 319.00
50 mg In stock $ 478.00
100 mg In stock $ 687.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.88%
Purity: 99.2%
Purity: 98.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
Targets&IC50 MDA-MB-231 cell:29.7 μM (IC50)
In vitro Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner, and induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated 'intrinsic' pathway [1]. Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner (IC50: 29.7 μM) [2].
Source
Synonyms Kushenol F, Vexibinol
Molecular Weight 424.49
Formula C25H28O6
CAS No. 97938-30-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (58.89 mM)

TargetMolReferences and Literature

1. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76. 2. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.

TargetMolCitations

1. Yan Y, Xia X, Fatima A, et al.Antibacterial Activity and Mechanisms of Plant Flavonoids against Gram-Negative Bacteria Based on the Antibacterial Statistical Model.Pharmaceuticals.2024, 17(3): 292.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Selected Plant-Sourced Compound Library Anti-Cancer Compound Library Tibetan medicine Compound Library NO PAINS Compound Library Traditional Mongolian Medicine Compound Library Bioactive Compound Library Natural Product Library Natural Product Library for HTS Antiparasitic Natural Product Library

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Keywords

Sophoraflavanone G 97938-30-2 Apoptosis Inhibitor anti-infammatory HL60 inhibit Kushenol F Vexibinol inhibitor

 

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