Neuronal Signaling Compound Library

Catalog No. L2600

Library Compound List Excel SDF

Communication between and within neurons is critical for all functions of the nervous system, from development to aging, through health and disease. The last decade has seen huge advances in our knowledge of the molecular, cellular and systematic signaling pathways within the nervous system. There have been significant breakthroughs in studies on the signaling pathways that underlie neurogenesis, addiction and autism spectrum disorders, as well as the pathophysiology and treatment of mood disorders. G protein-coupled receptors(GPCRs), including 5-HT receptors, histamine receptors, opioid receptors, are the largest family of signaling proteins to neuronal signaling. Changes in the GPCRs functioning can cause diseases many Neurological Disorders; Notch signaling is essential for proliferation, survival, self-renew, and differentiation of neural stem cells (NSCs). Notch signaling in neurons, glia and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer’s disease and CNS tumors. Therefore, the potential of agents that target notch signaling could be used as therapeutic interventions for several different CNS disorders.

The Neuronal Signaling Compound Library by TargetMol, containing 2540 compounds targeting CNS signaling, can be used for high throughput screening and high content screening for new drugs in neurological disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

Request Library

Product Description

A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
Bioactivity and safety confirmed by pre-clinical research and clinical trials;
Targets include 5-HT receptor, AChR, Histamine receptor, dopamine receptor, Opioid receptor, etc;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

See More... Hide

Library Composition

5-HT Receptor (334)

AChR (292)

COX (263)

Adrenergic Receptor (228)

Dopamine Receptor (220)

Calcium Channel (170)

Histamine Receptor (157)

GABA Receptor (131)

GluR (121)

Autophagy (118)

TRP/TRPV Channel (114)

Apoptosis (104)

Endogenous Metabolite (101)

iGluR (88)

AChE (86)

Adenosine Receptor (79)

Opioid Receptor (75)

NMDAR (73)

MAO (62)

Beta Amyloid (57)

Antibacterial (53)

NF-κB (45)

Monoamine Oxidase (43)

P-gp (42)

Potassium Channel (39)

Cannabinoid Receptor (38)

Serotonin Transporter (38)

Parasite (37)

P2X Receptor (36)

Gamma-secretase (36)

Norepinephrine (34)

Sodium Channel (34)

CaMK (31)

P450 (30)

FAAH (27)

Sigma receptor (23)

NO Synthase (22)

Reactive Oxygen Species (22)

Neurokinin receptor (22)

P2Y Receptor (20)

GPR (19)

Lipoxygenase (18)

PDE (18)

Antibiotic (18)

TNF (17)

HIV Protease (17)

OX Receptor (17)

Influenza Virus (17)

PPAR (17)

Neuropeptide Y Receptor (16)

Mitophagy (14)

Ferroptosis (14)

BACE (14)

Antifungal (13)

Beta-Secretase (12)

NOS (12)

Prostaglandin Receptor (12)

ERK (11)

IL Receptor (11)

Melanocortin Receptor (11)

Antioxidant (10)

Imidazoline Receptor (10)

Melatonin Receptor (10)

Phospholipase (10)

Drug Metabolite (9)

Caspase (9)

Virus Protease (9)

PGE Synthase (8)

MT Receptor (8)

HDAC (8)

ROS (8)

p38 MAPK (8)

DNA/RNA Synthesis (8)

HSV (7)

Akt (7)

GlyT (7)

SARS-CoV (7)

Interleukin (7)

AMPK (7)

Adenylyl cyclase (7)

Chloride channel (7)

HER (7)

Transferase (7)

BCL (6)

Estrogen/progestogen Receptor (6)

Glucocorticoid Receptor (6)

EGFR (6)

PKA (6)

MRP (6)

PKC (6)

HCV Protease (5)

IκB/IKK (5)

MMP (5)

STAT (5)

Carbonic Anhydrase (5)

Tyrosinase (5)

Dehydrogenase (5)

Microtubule Associated (5)

Glutathione Peroxidase (5)

Monoamine Transporter (4)

PI3K (4)

GSK-3 (4)

TLR (4)

CGRP Receptor (4)

NADPH (4)

Histone Demethylase (4)

PARP (4)

TGF-beta/Smad (4)

Histone Methyltransferase (4)

HIF/HIF Prolyl-Hydroxylase (4)

cholecystokinin (4)

AAK1 (AP2 associated kinase 1) (4)

Antifection (3)

ABC (3)

RAAS (3)

JNK (3)

Topoisomerase (3)

ATPase (3)

Phosphatase (3)

Immunology/Inflammation related (3)

Na+/Ca2+ Exchanger (3)

VEGFR (3)

PAFR (3)

Mitochondrial Metabolism (3)

Melanin-concentrating Hormone Receptor (MCHR) (3)

CCR (3)

Wnt/beta-catenin (3)

GST (3)

MEK (3)

Src (3)

transporter (3)

Anti-infection (3)

Neurotensin Receptor (3)

Serine/threonin kinase (3)

GluCls (2)

RSV (2)

Lipase (2)

advanced glycation end products (2)

BCRP (2)

Reductase (2)

Nrf2 (2)

DYRK (2)

IFNAR (2)

Acyltransferase (2)

Free radical scavengers (2)

Transaminase (2)

Amino Acids and Derivatives (2)

Hydroxylase (2)

cAMP (2)

mTOR (2)

PAK (2)

IAP (2)

ROCK (2)

UGT (2)

LDL (2)

Leukotriene Receptor (2)

CDK (2)

DNA Methyltransferase (2)

FAK (2)

NOD (2)

Guanylate cyclase (2)

Estrogen Receptor/ERR (2)

HBV (2)

Androgen Receptor (2)

JAK (2)

Aurora Kinase (2)

Progesterone Receptor (2)

Gap Junction Protein (2)

CaSR (2)

DNA (2)

IGF-1R (2)

Epoxide Hydrolase (2)

Epigenetic Reader Domain (2)

Thrombin (1)

NOD-like Receptor (NLR) (1)

CFTR (1)

S6 Kinase (1)

HMG-CoA Reductase (1)

ROS Kinase (1)

lysosomal autophagy (1)

FGFR (1)

AhR (1)

NMU2R (1)

Platelet aggregation (1)

NADPH-oxidase (1)

Syk (1)

Adenosine deaminase (1)

p53 (1)

FLT (1)

Protease-activated Receptor (1)

Bombesin Receptor (1)

CRISPR/Cas9 (1)

cell cycle arrest (1)

Bcr-Abl (1)

Adiponectin receptor (1)

FLAP (1)

Annexin A (1)

Myosin (1)

Aryl Hydrocarbon Receptor (1)

FXR (1)

Cysteine Protease (1)

Antifolate (1)

GRK (1)

N-Acetylglucosaminyltransferase (1)

OCT (1)

GTPase (1)

Neuropeptide W (1)

LPL Receptor (1)

Integrin (1)

ROR (1)

Monocarboxylate transporter (1)

CAT (1)

Raf (1)

Glucagon Receptor (1)

Retinoid Receptor (1)

Antiviral (1)

Reverse Transcriptase (1)

Casein Kinase (1)

Histone Acetyltransferase (1)

Sirtuin (1)

GPCR19 (1)

Aminopeptidase (1)

Trk receptor (1)

STING (1)

HSP (1)

MAPK (1)

Glucosidase (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

ACK (1)

PAD (1)

Somatostatin (1)

Stearoyl-CoA Desaturase (SCD) (1)

Proteasome (1)

Fatty Acid Synthase (1)

MAGL (1)

Anion Exchanger (1)

S1P Receptor (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty