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Lifarizine

Catalog No. T27830 CAS 119514-66-8

Synonyms: RS 87476, RS 87476-000, RS-87476, RS-87476-000, RS87476

Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.

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Lifarizine, CAS 119514-66-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 146.00
5 mg	In stock	$ 350.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00

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Purity: 99.12%

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Description

Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.

In vivo

Verofylline (0.05 mg/kg; oral; asthma patients) subject tolerance was good at the doses used. Dose-response curves for mean forced expiratory volume in one second, peak expiratory flow rate, and forced expiratory flow at the end of 4 hr were greater after 0.05 mg/kg verofylline than after placebo or higher doses of verofylline. Mean percent change in forced vital capacity remained increased as long as 6 hr after 0.15 mg/kg active drug. Verofylline was not very effective as a bronchodilator at the doses used.[1]

Synonyms	RS 87476, RS 87476-000, RS-87476, RS-87476-000, RS87476
Molecular Weight	436.59
Formula	C29H32N4
CAS No.	119514-66-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. McGivern JG, et al. Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115. Br J Pharmacol. 1995;114(8):1738-1744. 2. MacKinnon AC, et al. [3H]-lifarizine, a high affinity probe for inactivated sodium channels. Br J Pharmacol. 1995;115(6):1103-1109. 3. Brown NA, et al. Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. Br J Pharmacol. 1994;113(2):600-606. 4. McBean DE, et al. Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. Br J Pharmacol. 1995;116(8):3093-3098.

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Keywords

Lifarizine 119514-66-8 Membrane transporter/Ion channel Metabolism Calcium Channel RS 87476 RS 87476-000 RS-87476 RS-87476-000 RS87476 inhibitor inhibit

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