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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16873 | SERCA2a activator 1 | Calcium Channel | |
SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart. | |||
T1198 | Tetracaine hydrochloride | Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl | Calcium Channel , Sodium Channel |
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... | |||
T4054 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene | Calcium Channel , Autophagy |
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t... | |||
T24239 | K201 | K-201,JTV 519,JTV-519,K 201 | Calcium Channel |
K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors. | |||
T8863 | VK-II-36 | Others | |
VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor. | |||
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T1435 | Praziquantel | Pyquiton,Droncit,Biltricide | Calcium Channel , Antibiotic , Parasite |
Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur... | |||
T5148 | Atosiban acetate | RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 | Oxytocin Receptor , Vasopressin Receptor |
Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... | |||
T80555 | Myoregulin TFA | MLN peptide TFA | Calcium Channel |
Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics. It specifically interacts with sarcoplasmic reticulum Ca2+-ATPase ... | |||
T11731 | JTV-519 free base | K201 free base | FLT |
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partia... | |||
T68320 | L594881 HCl | ||
L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sar... | |||
T26383 | 3',4'-Dichlorobenzamil HCl | ||
3',4'-Dichlorobenzamil HCl is an inhibitor of Na+ transport, Na+/Ca2+ exchanger, sarcoplasmic reticulum Ca2+ release channels. | |||
T80556 | Wt hMLN | Calcium Channel | |
Wild-type human myoregulin (wt hMLN) is a microprotein that inhibits the sarcoplasmic reticulum Ca²⁺ pump (SERCA), playing a crucial role in the regulation of calcium homeostasis in skeletal muscle [1]. | |||
T80554 | Myoregulin | MLN peptide | Calcium Channel |
Myoregulin (MLN peptide), a regulin family member, modulates muscle performance through intracellular calcium handling. It directly interacts with the sarcoplasmic reticulum Ca^2+-ATPase (SERCA), impeding Ca^2+ uptake in... | |||
T26830 | BK 129 | BK-129,BK129 | |
BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum. | |||
T15599 | Istaroxime hydrochloride | PST2744 hydrochloride | Others |
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. | |||
T11732 | JTV-519 hemifumarate | K201 hemifumarate | MELK |
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. | |||
T14293 | Annonacin | Others | |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarco... | |||
T68366 | Azumolene sodium dihydrate | ||
Azumolene sodium dihydrate is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus... |