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Naringenin

Catalog No. T2838 CAS 480-41-1

Synonyms: Naringetol, S-Dihydrogenistein, Pelargidanon, Salipurol, NSC 11855, NSC 34875

Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.

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Naringenin, CAS 480-41-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 50.00
100 mg	In stock	$ 53.00
500 mg	In stock	$ 81.00
1 g	In stock	$ 120.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98.81%

Purity: 98.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
In vitro	In both normoglycemic and non-insulin-dependent diabetes mellitus rat models, oral administration of 50 mg/kg Naringenin resulted in a significant decrease in plasma glucose levels.
In vivo	Naringenin, found in grapefruit juice, has been demonstrated to inhibit the human cytochrome P450 isoform CYP1A2. This can adversely alter the pharmacokinetics of several common agents in human (or directly homologous) hosts, potentially rendering otherwise harmless substances carcinogenic.
Cell Research	Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay[1].
Source	Natural Products > Rutaceae > Citrus

Synonyms	Naringetol, S-Dihydrogenistein, Pelargidanon, Salipurol, NSC 11855, NSC 34875
Molecular Weight	272.25
Formula	C15H12O5
CAS No.	480-41-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (183.6 mM)

Ethanol: 5 mg/mL (18.36 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Fuhr U, et al. Br J Clin Pharmacol, 1993, 35(4):431-436. 2. Ortiz-Andrade RR, et al. Diabetes Obes Metab, 2008, 10(11), 1097-1104. 3. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051.

Citations

1. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet. Molecules. 2019, 24(17): 3051

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Miao medicine Compound Library Tobacco Monomer Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Fibrosis Compound Library Bioactive Compounds Library Max Anti-Inflammatory Traditional Chinese Medicine Compound Library DNA Damage & Repair Compound Library Target-Focused Phenotypic Screening Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Naringenin 480-41-1 DNA Damage/DNA Repair Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb P450 Influenza Virus Reactive Oxygen Species PPAR Endogenous Metabolite NSC-11855 Naringetol S-Dihydrogenistein Pelargidanon Salipurol NSC11855 NSC 11855 NSC34875 NSC-34875 NSC 34875 inhibitor inhibit

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