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Naringenin

Name: Naringenin
Brand: TargetMol
SKU: T2838
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2838Cas No. 480-41-1

Alias S-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, Naringetol

Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.

Naringenin

🥰Excellent

Purity: 99.52%

Catalog No. T2838Alias S-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, NaringetolCas No. 480-41-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$50	In Stock	In Stock
100 mg	$53	In Stock	In Stock
500 mg	$81	In Stock	In Stock
1 g	$120	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
In vitro	In both normoglycemic and non-insulin-dependent diabetes mellitus rat models, oral administration of 50 mg/kg Naringenin resulted in a significant decrease in plasma glucose levels.
In vivo	Naringenin, found in grapefruit juice, has been demonstrated to inhibit the human cytochrome P450 isoform CYP1A2. This can adversely alter the pharmacokinetics of several common agents in human (or directly homologous) hosts, potentially rendering otherwise harmless substances carcinogenic.
Cell Research	Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay[1].
Synonyms	S-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, Naringetol

Chemical Properties

Molecular Weight	272.25
Formula	C₁₅H₁₂O₅
Cas No.	480-41-1
Smiles	O=C1C=2C(O[C@@H](C1)C3=CC=C(O)C=C3)=CC(O)=CC2O
Relative Density.	1.485g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (367.31 mM), Sonication is recommended.

Ethanol: 5 mg/mL (18.37 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6731 mL	18.3655 mL	36.7309 mL	183.6547 mL
5 mM	0.7346 mL	3.6731 mL	7.3462 mL	36.7309 mL
10 mM	0.3673 mL	1.8365 mL	3.6731 mL	18.3655 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1837 mL	0.9183 mL	1.8365 mL	9.1827 mL
50 mM	0.0735 mL	0.3673 mL	0.7346 mL	3.6731 mL
100 mM	0.0367 mL	0.1837 mL	0.3673 mL	1.8365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc