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Melatonin

Catalog No. T1659 CAS 73-31-4

Synonyms: Melatonine, N-Acetyl-5-methoxytryptamine

Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

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Melatonin, CAS 73-31-4

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Purity: 99.79%

Purity: 99.78%

Purity: 98.71%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Melatonin modulates various signaling pathways by increasing the levels of activated PTEN, RSK-1, mTOR, and AMPKα kinases, while mildly reducing ERK-1/2 and Bad phosphorylation. It significantly decreases the phosphorylation of S6 Ribosomal Protein, 4E-BP1, GSK-3α, and GSK-3β, and marginally enhances PRAS40 phosphorylation in animals. Moreover, melatonin mitigates neurotoxicity and astrocyte activation caused by Aβ1-42 in the cerebral cortex and prevents the suppression of Reelin and Dab1 expression triggered by Aβ1-42. Comparable effects to melatonin treatment are observed in the absence of NLRP3-/-, including similar reductions in NF-κB and NLRP3 signaling pathways and akin alterations in clock genes expression, alongside improvements in cardiomyocytes morphology in mice.

Synonyms	Melatonine, N-Acetyl-5-methoxytryptamine
Molecular Weight	232.28
Formula	C13H16N2O2
CAS No.	73-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.6 mg/mL (50 mM)

References and Literature

1. Reiter RJ, et al. J Biomed Sci, 2000, 7(6), 444-458. 2. Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384. 3. Reiter RJ, et al. Cell Biochem Biophys, 2001, 34(2), 237-256. 4. Vanecek J, et al. Physiol Rev, 1998, 78(3), 687-721. 5. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665. 6. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 7. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 8. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Citations

1. Chen J, Zhang L G, Du H X, et al. Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1‐dependent inhibition of the NLRP3 inflammasome in an EAP mouse model. The Prostate. 2021 2. Xue K H, Jiang Y F, Bai J Y, et al.Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect.Redox Report.2023, 28(1): 2251234.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Drug Library EMA Approved Drug Library GPCR Compound Library Membrane Protein-targeted Compound Library Human Endogenous Metabolite Library Anti-Cancer Clinical Compound Library Traditional Chinese Medicine Monomer Library Inhibitor Library

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Keywords

Melatonin 73-31-4 Apoptosis Autophagy Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Mitophagy CaMK Melatonin Receptor Estrogen/progestogen Receptor Endogenous Metabolite Glutathione Peroxidase ROR inhibit Mitochondrial Autophagy Melatonine Inhibitor N-Acetyl-5-methoxytryptamine inhibitor

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