Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective Antioxidant.
Description | Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant. |
In vivo | Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[5]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[6]. |
Synonyms | Melatonine, N-Acetyl-5-methoxytryptamine |
Molecular Weight | 232.28 |
Formula | C13H16N2O2 |
CAS No. | 73-31-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 11.6 mg/mL (50 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Melatonin 73-31-4 Apoptosis Autophagy Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Glutathione Peroxidase Endogenous Metabolite ROR Mitophagy CaMK Melatonin Receptor Estrogen/progestogen Receptor Melatonine inhibit N-Acetyl-5-methoxytryptamine Mitochondrial Autophagy Inhibitor inhibitor