Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
2 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 438.00 | |
50 mg | In stock | $ 649.00 | |
100 mg | In stock | $ 926.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 177.00 |
Description | MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
In vitro | In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1]. |
In vivo | MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2]. |
Synonyms | MMPIP hydrochloride (479077-02-6 Free base) |
Molecular Weight | 369.8 |
Formula | C19H16ClN3O3 |
CAS No. | 1215566-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.7 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MMPIP hydrochloride 1215566-78-1 Neuroscience GluR 479077-02-6 MMPIP Hydrochloride MMPIP system MMPIP hydrochloride (479077-02-6 Free base) nervous neuropathic behavior pain inhibit central glutamate cognitive allosteric Metabotropic glutamate receptors 479077-02-6 Free base Inhibitor metabotropic mGluR mGluR7 inhibitor