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L67

Catalog No. T3103 CAS 325970-71-6

Synonyms: DNA Ligase Inhibitor

L67 is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

L67, CAS 325970-71-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L67 is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).
Targets&IC50	DNA ligasesIII:10 μM, DNA ligases I:10 μM

Synonyms	DNA Ligase Inhibitor
Molecular Weight	486.12
Formula	C16H14Br2N4O4
CAS No.	325970-71-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: >10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chen X, et al. Y Res. 2008 May 1;68(9):3169-3177.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Toxic Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L67 325970-71-6 DNA损伤和修复细胞周期 DNA DNA/RNA Synthesis Reactive Oxygen Species DNA Ligase Inhibitor Apoptosis L 67 HeLa Inhibitor DNA damage mSOX inhibit ROS mitochondrial L-67 caspase 1 γH2AX Caspase inhibitor

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