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L-2-Hydroxyglutaric acid disodium

Catalog No. T13748 CAS 63512-50-5

Synonyms: (S)-2-Hydroxyglutaric acid disodium

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).

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L-2-Hydroxyglutaric acid disodium, CAS 63512-50-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 52.00
25 mg	In stock	$ 92.00
50 mg	In stock	$ 149.00
100 mg	In stock	$ 201.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity(Km and Ki of 2.52 mM and 11.13 mM, respectively).
In vitro	L-2-hydroxyglutarate can effectively inhibit 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs), including eleven eleven translocation (TET) enzymes [2].

Synonyms	(S)-2-Hydroxyglutaric acid disodium
Molecular Weight	194.094
Formula	C5H8Na2O5
CAS No.	63512-50-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24. 2. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.

Related compound libraries

This product is contained In the following compound libraries：

Stem Cell Differentiation Compound Library Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Epigenetics Compound Library Glycometabolism Compound Library Cuproptosis Compound Library Anti-Metabolism Disease Compound Library Bioactive Compound Library Histone Modification Compound Library Anti-Aging Compound Library

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Keywords

L-2-Hydroxyglutaric acid disodium 63512-50-5 Chromatin/Epigenetic Metabolism Histone Demethylase Mitochondrial Metabolism L 2 Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium modifier demethylases methylation Inhibitor renal cancer epigenetic inhibit histone L2Hydroxyglutaric acid disodium inhibitor

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