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Griseofulvin

Catalog No. T1382 CAS 126-07-8

Synonyms: Fulvicin, Amudane, Grisactin

Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.

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Griseofulvin, CAS 126-07-8

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500 mg	In stock	$ 41.00

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Purity: 95.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
In vitro	Griseofulvin exhibits effective anti-infective activity in vivo. When administered in conjunction with nocodazole (5 mg/kg), Griseofulvin significantly enhances the efficacy of nocodazole, resulting in the cessation of tumor growth.
In vivo	In vitro tests have demonstrated that the minimum inhibitory concentration (MIC) of Griseofulvin against various dermatophytes ranges between 0.14 to 0.6 µg/mL. Griseofulvin's primary mechanism of action on cellular mitosis is the disassembly of spindle microtubules. Additionally, Griseofulvin has the capacity to induce chromosomal structural abnormalities in mammalian cells. It is effective in combating different types of skin fungi, including species from the genera Microsporum, Trichophyton, and Epidermophyton. However, it is not sensitive to other fungi, such as Scopulariopsis and Hendersonula, and has almost no effect on yeasts.
Cell Research	The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference)

Synonyms	Fulvicin, Amudane, Grisactin
Molecular Weight	352.77
Formula	C17H17ClO6
CAS No.	126-07-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 47 mg/mL (133.2 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. De Carli L, et al. Mutat Res, 1988, 195(2), 91-126. 2. Ho YS, et al. Int J Cancer, 2001, 91(3), 393-401. 3. Rajendran P, et al. Clin Cancer Res, 2011, 17(6), 1425-1439.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Microbial Natural Product Library Microtubule-Targeted Compound Library Approved Drug Library Antibiotics Library Human Metabolite Library Anti-Fungal Compound Library

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Keywords

Griseofulvin 126-07-8 Apoptosis Cytoskeletal Signaling Microbiology/Virology Antibiotic Antifungal Microtubule Associated Fungal Fulvicin Inhibitor Amudane inhibit Grisactin inhibitor

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