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Flufenamic acid

Catalog No. T0858 CAS 530-78-9

Synonyms: Arlef, Nichisedan, Achless

Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.

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Flufenamic acid, CAS 530-78-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 47.00
200 mg	In stock	$ 60.00
500 mg	In stock	$ 95.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Under peak amyloid fibril formation conditions (pH 4.4), Flufenamic acid binds to wild-type transthyretin (KD1=30 nM, KD2=255 nM), V30M transthyretin (KD1=41 nM, KD2=320 nM), and L55P transthyretin (KD1=74 nM, KD2=682 nM) with high affinity and negative cooperativity (pH value 7.6), fully inhibiting fibril formation at a concentration of 10.8 μM. In Xenopus oocytes, Flufenamic acid reversibly suppresses ICl(Ca) in a dose-dependent manner, with an IC50 of 28 mM, without affecting the shape of the current-voltage curve in response to depolarizing voltage. Flufenamic acid inhibits the calcium-activated non-selective cation channels in the basolateral membrane of rat pancreatic exocrine cells activated by an inward-outward patch with an IC50 of 10 μM. The compound also inhibits currents activated by intracellular ADP-ribose in recombinant human TRPM2 (hTRPM2) channels and the CRI-G1 rat insulinoma cell line. Additionally, it reversibly inhibits (IC50=13.8 μM) DAP and phase discharge in rat suprachiasmatic neurons with similar kinetics, without significantly affecting membrane potential, spike threshold, or input resistance (P > 0.05), nor does it significantly affect the frequency and amplitude of spontaneous synaptic potentials.

Synonyms	Arlef, Nichisedan, Achless
Molecular Weight	281.23
Formula	C14H10F3NO2
CAS No.	530-78-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 28.1 mg/mL (100 mM)

DMSO: 28.1 mg/mL (100 mM)

References and Literature

1. White MM, et al. Mol Pharmacol, 1990, 37(5), 720-724. 2. Gögelein H, et al. FEBS Lett, 1990, 268(1), 79-82. 3. Baures PW, et al. Bioorg Med Chem, 1999, 7(7), 1339-1347. 4. Hill K, et al. Neuropharmacology, 2004, 47(3), 450-460. 5. Ghamari-Langroudi M et al. J Physiol, 2002, 545(Pt 2), 537-542. 6. Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104. 7. Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Human Metabolite Library Epigenetics Compound Library Neuronal Signaling Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Anti-Parasitic Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flufenamic acid 530-78-9 Chromatin/Epigenetic Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience PI3K/Akt/mTOR signaling COX AMPK Parasite Potassium Channel Calcium Channel Chloride channel Arlef Cl? Channels Ca channels Nichisedan Ca2+ channels Cyclooxygenase Inhibitor inhibit Chloride Channel AMP-activated protein kinase KcsA Achless inhibitor

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