store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it also is a selective Constitutive androstane receptor (CAR) agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 57.00 | |
10 mg | In stock | $ 91.00 | |
25 mg | In stock | $ 166.00 | |
50 mg | In stock | $ 266.00 | |
100 mg | In stock | $ 397.00 | |
200 mg | In stock | $ 597.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 63.00 |
Description | CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it also is a selective Constitutive androstane receptor (CAR) agonist. |
In vitro | CITCO (1-50 μM; 48?hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (0-25?μM; 48?hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly. CITCO (2.5-10?μM; 48?hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (2.5, 5?μM; 48?hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes[1]. |
In vivo | CITCO (intraperitoneal; 25?μg; on days 22, 24, 26, 30 and 36) results a significant decrease in tumour growth. After treatment with 100?μg CITCO, it further decreases to an undetectable level [1]. |
Molecular Weight | 436.74 |
Formula | C19H12Cl3N3OS |
CAS No. | 338404-52-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: insoluble
DMSO: 11 mg/ml (25.19 mM)
You can also refer to dose conversion for different animals. More
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CITCO 338404-52-7 Apoptosis Others Inhibitor inhibit inhibitor