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6-Thioguanine

Catalog No. T3089 CAS 154-42-7

Synonyms: 2-Amino-6-mercaptopurine, Thioguanine, 6-TG, 2-Amino-6-purinethiol

Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

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6-Thioguanine, CAS 154-42-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 48.00
500 mg	In stock	$ 72.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 98.75%

Purity: 98.34%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50	USP2:40 μM, Plpros:25 μM

Synonyms	2-Amino-6-mercaptopurine, Thioguanine, 6-TG, 2-Amino-6-purinethiol
Molecular Weight	167.2
Formula	C5H5N5S
CAS No.	154-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 14 mg/mL (83.7 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Krynetskaia NF, et al. FASEB J, 2000, 14(14), 2339-2344. 2. Marathias VM, et al. Nucleic Acids Res,1999, 27(14), 2860-2867. 3. Yamane K, et al. Clin Cancer Res,2005, 11(6), 2355-2363. 4. Brem R, et al. Photochem Photobiol,2012, 88(1), 5-13. 5. Issaeva N, et al. Cancer Res,2010, 70(15), 6268-6276. 6. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55. 7. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.

Citations

1. Łagosz-Ćwik K, Melnykova M, Nieboga E, et al.Mapping of DNA methylationsensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis.Frontiers in Immunology.2023, 14.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Pediatric Drug Library Hematonosis Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Drug Library Inhibitor Library ReFRAME Related Library Methylation Compound Library Cell Cycle Compound Library

Related Products

Related compounds with same targets

Lecithin Inosine-5'-triphosphate trisodium salt Spaglumic acid acetate Oleic acid Dihydroxyfumaric acid hydrate Uridine triphosphate 4-Hydroxyphenylpyruvic acid Ecdysone

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

6-Thioguanine 154-42-7 Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Ubiquitination Endogenous Metabolite DUB SARS-CoV DNA Methyltransferase 2-Amino-6-mercaptopurine 6 Thioguanine Thioguanine SARS coronavirus Deubiquitinase DUBs DNMTs inhibit DNA MTases Inhibitor 6-TG 2-Amino-6-purinethiol 6Thioguanine inhibitor

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