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Catalog No. T3089   CAS 154-42-7
Synonyms: 2-Amino-6-mercaptopurine, Thioguanine, 6-TG, 2-Amino-6-purinethiol

Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

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6-Thioguanine Chemical Structure
6-Thioguanine, CAS 154-42-7
Pack Size Availability Price/USD Quantity
50 mg In stock $ 40.00
100 mg In stock $ 48.00
500 mg In stock $ 72.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 98.75%
Purity: 98.34%
Purity: 98.34%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50 USP2:40 μM, Plpros:25 μM
Synonyms 2-Amino-6-mercaptopurine, Thioguanine, 6-TG, 2-Amino-6-purinethiol
Molecular Weight 167.2
Formula C5H5N5S
CAS No. 154-42-7


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 14 mg/mL (83.7 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Krynetskaia NF, et al. FASEB J, 2000, 14(14), 2339-2344. 2. Marathias VM, et al. Nucleic Acids Res,1999, 27(14), 2860-2867. 3. Yamane K, et al. Clin Cancer Res,2005, 11(6), 2355-2363. 4. Brem R, et al. Photochem Photobiol,2012, 88(1), 5-13. 5. Issaeva N, et al. Cancer Res,2010, 70(15), 6268-6276. 6. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55. 7. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.


1. Łagosz-Ćwik K, Melnykova M, Nieboga E, et al.Mapping of DNA methylationsensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis.Frontiers in Immunology.2023, 14.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Pediatric Drug Library Hematonosis Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Drug Library Inhibitor Library ReFRAME Related Library Methylation Compound Library Cell Cycle Compound Library

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Lecithin Inosine-5'-triphosphate trisodium salt Spaglumic acid acetate Oleic acid Dihydroxyfumaric acid hydrate Uridine triphosphate 4-​Hydroxyphenylpyruvic acid Ecdysone

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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6-Thioguanine 154-42-7 Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Ubiquitination Endogenous Metabolite DUB SARS-CoV DNA Methyltransferase 2-Amino-6-mercaptopurine 6 Thioguanine Thioguanine SARS coronavirus Deubiquitinase DUBs DNMTs inhibit DNA MTases Inhibitor 6-TG 2-Amino-6-purinethiol 6Thioguanine inhibitor