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6-Thioguanine

Catalog No. T3089 CAS 154-42-7

Synonyms: Thioguanine, 2-Amino-6-mercaptopurine, 6-TG, 6-硫代鸟嘌呤, 2-Amino-6-purinethiol

Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

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6-Thioguanine, CAS 154-42-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Targets&IC50	USP2:40 μM, Plpros:25 μM

Synonyms	Thioguanine, 2-Amino-6-mercaptopurine, 6-TG, 6-硫代鸟嘌呤, 2-Amino-6-purinethiol
Molecular Weight	167.19
Formula	C5H5N5S
CAS No.	154-42-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 14 mg/mL (83.7 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Krynetskaia NF, et al. FASEB J, 2000, 14(14), 2339-2344. 2. Marathias VM, et al. Nucleic Acids Res,1999, 27(14), 2860-2867. 3. Yamane K, et al. Clin Cancer Res,2005, 11(6), 2355-2363. 4. Brem R, et al. Photochem Photobiol,2012, 88(1), 5-13. 5. Issaeva N, et al. Cancer Res,2010, 70(15), 6268-6276. 6. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55. 7. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library HIF-1 Signaling Pathway Compound Library Hematonosis Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Nucleotide Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library

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You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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