Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 40.00 | |
100 mg | In stock | $ 48.00 | |
500 mg | In stock | $ 72.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | 6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. |
Targets&IC50 | USP2:40 μM, Plpro:25 μM |
In vitro | 6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies. |
In vivo | 6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells. |
Synonyms | 6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine, Thioguanine |
Molecular Weight | 167.19 |
Formula | C5H5N5S |
CAS No. | 154-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14 mg/mL (83.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
6-Thioguanine 154-42-7 Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Ubiquitination Endogenous Metabolite DUB SARS-CoV DNA Methyltransferase 6-TG 6 Thioguanine SARS coronavirus Deubiquitinase DUBs DNMTs inhibit DNA MTases 2-Amino-6-purinethiol Inhibitor 2-Amino-6-mercaptopurine Thioguanine 6Thioguanine inhibitor