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MSU-42011

Catalog No. T77499 CAS 2456434-36-7

MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated antitumor activity in a kras-driven mouse model of lung cancer.MSU-42011 is an effective therapy for the treatment of preclinical krasdriven lung cancer and has immunomodulatory activity.

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MSU-42011, CAS 2456434-36-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 463.00
100 mg	In stock	$ 747.00
500 mg	In stock	$ 1,520.00

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Purity: 99.04%

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Description	MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated antitumor activity in a kras-driven mouse model of lung cancer.MSU-42011 is an effective therapy for the treatment of preclinical krasdriven lung cancer and has immunomodulatory activity.
Targets&IC50	iNOS:158 nM
In vitro	MSU-42011 (300 nM; 8 h) showed a low induction effect on SREBP in HepG2 cells.[1] MSU-42011 (0-5000 nM; 24 h) can activate RXR in HepG2 cells.[1]
In vivo	MSU-42011 (25 mg/kg; oral; for 12 weeks) significantly reduced the number, size, and overall tumor burden of tumors in the A/J mouse lung cancer model. Compared with the control group, there were fewer cells with active proliferation and showed a significant decrease in p-ERK [1]. MSU-42011 (25 mg/kg; oral; single dose) is most effective in reducing the number, size, and overall tumor burden of the A/J mouse lung cancer model in combination with C/P. Reduced macrophages in the lungs and increased activation markers of CD8+T cells [1]. MSU42011 (100 mg/kg; PO; single dose) reduces tumor burden in a mouse lung tumor model [2].

Molecular Weight	382.54
Formula	C24H34N2O2
CAS No.	2456434-36-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Moerland JA, et al. The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer. Sci Rep. 2020;10(1):22244. Published 2020 Dec 17. 2. Leal AS, et al. The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer. Cancers (Basel). 2021;13(19):5004.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

MSU-42011 2456434-36-7 Apoptosis Immunology/Inflammation Metabolism NO Synthase PERK Retinoid Receptor Lipid NOS MSU42011 6((3,5ditertbutylphenyl)(isobutyl)amino)nicotinicacid MSU 42011 inhibitor inhibit

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