store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 74.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression. |
In vitro | S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml. |
Source |
Synonyms | Alpha-caryophyllene |
Molecular Weight | 204.35 |
Formula | C15H24 |
CAS No. | 6753-98-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ether: Soluble
DMSO: 50 mg/mL (244.68 mM)
Ethanol: Soluble
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α-Humulene 6753-98-6 Apoptosis Immunology/Inflammation Neuroscience NOS TNF COX Alpha-caryophyllene α Humulene Inhibitor Humulene a-caryophyllene αHumulene inhibit Nitric oxide synthases α-Caryophyllene Cyclooxygenase α-caryophyllene alpha-Humulene NO Synthase a-Humulene inhibitor