transgenic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T14690	BMS 433796	BMS-289948,BMS-299897	Beta Amyloid
	BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.		Beta Amyloid
T9253	CPFX4158		Antibacterial
	CPFX4158 is a mannose deriviative and an antibacterial agent that is potentially useful in transgenic humanized- CEACAM6 mouse.		Antibacterial
T60086	TTBK1-IN-2	N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Microtubule Associated
	TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures ...		Microtubule Associated
T77342	GSK-3 inhibitor 3		GSK-3 , Microtubule Associated
	GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ...		GSK-3 , Microtubule Associated
T11016	DGAT-1 inhibitor 2		Transferase
	DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s...		Transferase
T9518	Inarigivir ammonium	ORI-9020 ammonium,SB-9200 ammonium	HBV
	Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (...		HBV
TP1541L	BDC2.5 mimotope 1040-31 acetate	BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base)	Others
	BDC2.5 mimotope 1040-31 acetate is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. It can stimulate BDC2.5 cells with cells showing good response to this mimotope. 1040-31 peptide is spec...		Others
T9901A-001	Relatlimab	BMS-986016	Others
	Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, bloc...		Others
T2S1865	Octyl gallate	Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8	Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV
	1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ...
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T32330	JWB1-84-1 3HCl	JWB1 84 1 3HCl,JWB1 84 1 trihydrochloride,JWB1-84-1 trihydrochloride,JWB1841 trihydrochloride
	JWB1-84-1 3HCl, as a neuroprotective agent, can act by improving cognitive performances in a transgenic mouse model of AD.
T69664	Umibecestat HCl
	Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD...
T38279	C2-8	C2-8
	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola...
T69540	MI-30
	MI-30 is a SARS-CoV-2 Protease inhibitor (IC50 = 17.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment, MI-30 significantly reduced lung viral loads and lung lesions.
T62198	AR524
	AR524 is a transgenic inhibitor with higher inhibitory activity than the known transgenic inhibitor kifunensine. AR524 inhibits the formation of human malignant cell spheroids at low concentrations (10 μM).
T32276	JAY2-22-33	JAY-2-22-33,JAY 2 22 33
	JAY2-22-33, as a neuroprotective agent, can act by significantly reducing Aβ toxicity by delaying paralysis and improving cognitive performances in a transgenic mouse model of AD.
T70059	ALT-946 HCl
	ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
T78807	YIAD-0205
	YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial AD mutations [1].
T68794	ALT-946 free base
	ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.