phosphatases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T18888	4-Methylumbelliferyl phosphate	4-MUP	Others
	4-Methylumbelliferyl phosphate (4-MUP) (4-MUP) is used as a fluorogenic substrate of alkaline phosphatases.		Others
T21980	PD 198306		MEK
	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.		MEK
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T16554	PNPP		Others
	PNPP is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays.		Others
T16350	NSC-87877		Apoptosis , Phosphatase
	NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).		Apoptosis , Phosphatase
T9325	2-(2-Aminothiazole-4-yl)-2-methoxyiminoa		Others
	2-(2-Aminothiazole-4-yl)-2-methoxyiminoa is an inhibitor of protein tyrosine phosphatases, which can lead to changes in cellular signaling pathways that affect cell behavior.		Others
T3045	Salubrinal		Apoptosis , Phosphatase , PERK , Autophagy , HSV
	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).		Apoptosis , Phosphatase , PERK , Autophagy , HSV
T34973	Tyrphostin 8	4-Hydroxybenzylidenemalononitrile	EGFR , GTPase
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances ...		EGFR , GTPase
T22276	Bis(maltolato)oxovanadium(IV)	BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase , Others
	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i...		Phosphatase , Others
T7084	2-Bromo-4'-hydroxyacetophenone	SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide	Phosphatase
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH...		Phosphatase
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T70523	RK-682
	RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).
T20421	Fluorescein diphosphate	Fluorescein diphosphate Tetraammonium salt,FDP
	Fluorescein diphosphate is a colorless and nonfluorescent substrate for alkaline phosphatases. The sequential alkaline phosphatase mediated hydrolysis of its two phosphate substituents yielding weakly fluorescent fluores...
T40846	3,5-Difluoro-L-tyrosine
	3,5-Difluoro-L-tyrosine is a functional and tyrosinase-resistant mimic of tyrosine, commonly utilized for evaluating the substrate specificity of protein tyrosine phosphatases (PTPs).
T13095	Tautomycin		Others
	Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticill...		Others
T68458	Fostriecin (free base)
	Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM...
T35877	MurA-IN-1
	MurA-IN-1 (compound 1a), a PTPRR inhibitor, exhibits IC50 values of 0.09 μM for PTPRR, 0.23 μM for PTP1B, 0.75 μM for PTPN7, and 0.8 μM for PTPN5, respectively, targeting a family of human MAPK-specific protein tyrosine ...
T38587	Chrysophanol triglucoside
	Chrysophanol triglucoside, an anthraquinone derivative obtained from Cassia obtusifolia, demonstrates inhibitory activity against protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase, with half-maximal inhibitory c...
T40968	MLS-0437605
	MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphata...
TP1698	Microcystin-LA
	Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively.