Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 55.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2]. |
Targets&IC50 | SHP1:43 μM (Ki, cell free), PTP1B:42 μM (Ki, cell free) |
Cell Research | Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis. |
Synonyms | SHP-1 Inhibitor II, PTP Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl bromide |
Molecular Weight | 215.04 |
Formula | C8H7BrO2 |
CAS No. | 2491-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 20 mg/mL
H2O: Insoluble
DMSO: 60 mg/mL (279.02 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
2-Bromo-4'-hydroxyacetophenone 2491-38-5 Metabolism Phosphatase SHP-1 Inhibitor II 2 Bromo 4' hydroxyacetophenone alpha-Bromo-4-hydroxyacetophenone a-Bromo-4-hydroxyacetophenone 2Bromo4'hydroxyacetophenone PTP Inhibitor I 4-Hydroxyphenacyl Bromide α-Bromo-4-hydroxyacetophenone 4-Hydroxyphenacyl bromide inhibit Inhibitor inhibitor