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Pentamidine dihydrochloride

Catalog No. T23132   CAS 50357-45-4
Synonyms: MP-601205 dihydrochloride

Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.

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Pentamidine dihydrochloride Chemical Structure
Pentamidine dihydrochloride, CAS 50357-45-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 75.00
25 mg In stock $ 128.00
50 mg In stock $ 192.00
100 mg In stock $ 287.00
200 mg In stock $ 431.00
500 mg In stock $ 713.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 98.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.
Targets&IC50 Leishmania infantum:2.5 μM
In vitro Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3].
In vivo Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3].
Synonyms MP-601205 dihydrochloride
Molecular Weight 413.34
Formula C19H26Cl2N4O2
CAS No. 50357-45-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36 mg/ml (87.10 mM)

TargetMolReferences and Literature

1. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. 2. David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49. 3. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. 4. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compound Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library NO PAINS Compound Library

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Keywords

Pentamidine dihydrochloride 50357-45-4 Metabolism Microbiology/Virology Phosphatase Antibacterial Antibiotic Parasite Antifungal PTP1B Pneumocystis Pentamidine MP601205 antitumor Inhibitor Kidney carinii Bacterial cell-cycle pneumonia inhibit MP 601205 MP-601205 DNA MP 601205 Dihydrochloride MP601205 Dihydrochloride Pentamidine Dihydrochloride biosynthetics MP-601205 Dihydrochloride Fungal arrest MP-601205 dihydrochloride inhibitor

 

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