Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 75.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 192.00 | |
100 mg | In stock | $ 287.00 | |
200 mg | In stock | $ 431.00 | |
500 mg | In stock | $ 713.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. |
Targets&IC50 | Leishmania infantum:2.5 μM |
In vitro | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
In vivo | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
Synonyms | MP-601205 dihydrochloride |
Molecular Weight | 413.34 |
Formula | C19H26Cl2N4O2 |
CAS No. | 50357-45-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/ml (87.10 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pentamidine dihydrochloride 50357-45-4 Metabolism Microbiology/Virology Phosphatase Antibacterial Antibiotic Parasite Antifungal PTP1B Pneumocystis Pentamidine MP601205 antitumor Inhibitor Kidney carinii Bacterial cell-cycle pneumonia inhibit MP 601205 MP-601205 DNA MP 601205 Dihydrochloride MP601205 Dihydrochloride Pentamidine Dihydrochloride biosynthetics MP-601205 Dihydrochloride Fungal arrest MP-601205 dihydrochloride inhibitor