p-p53 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T34830	Tetrofosmin	P 53,P53
	Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.
TP1794	p53 (17-26)	p53 17-26
	This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2.
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)		Apoptosis , PDK
TP2281	p53 tumor suppressor fragment		Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial ...		Others
T12350	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride		Others
	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.		Others
T9150	SCR130	1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-	Apoptosis , Others , DNA/RNA Synthesis
	SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) is enzyme inhibition, antiproliferative effects and antifungal activity.		Apoptosis , Others , DNA/RNA Synthesis
T12351	p53 and MDM2 proteins-interaction-inhibitor (racemic)	p53-and-mdm2-proteins-interaction-inhibitor-racemic	Others
	p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.		Others
TP2299	Tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]		Others
	Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA...		Others
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T69115	Nutlin-1
	Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent.
T21978	p-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Mor...
T61369	p53 Activator 2
	p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant DNA double-strand breaks and upregulates the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces ...
TN5201	Uncarinic acid E		BCL , MEK , Caspase , PI3K , Antifection , p53
	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu...		BCL , MEK , Caspase , PI3K , Antifection , p53
T78569	CPT2	Carnitine palmitoyltransferase 2	Apoptosis
	Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC). Overexpression of CPT2 activates phosphorylated p53, enhancing its expres...		Apoptosis
T36108	YW3-56 (hydrochloride) (technical grade)	YW3-56 (hydrochloride) (technical grade)
	YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of ...