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PDK4-IN-1 hydrochloride

PDK4-IN-1 hydrochloride
PDK4-IN-1 hydrochloride, an anthraquinone derivative, is a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 value of 84 nM.
Catalog No. T12412LCas No. 2310262-11-2
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Purity:99.54%
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PDK4-IN-1 hydrochloride

Catalog No. T12412LCas No. 2310262-11-2
PDK4-IN-1 hydrochloride, an anthraquinone derivative, is a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 value of 84 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$129In Stock
5 mg$316In Stock
10 mg$482In Stock
25 mg$789In Stock
50 mg$1,080In Stock
100 mg$1,480In Stock
500 mg$2,970In Stock
1 mL x 10 mM (in DMSO)$347In Stock
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Product Introduction

Bioactivity
Description
PDK4-IN-1 hydrochloride, an anthraquinone derivative, is a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 value of 84 nM.
Targets&IC50
PDK4:84 nM
In vitro
PDK4-IN-1 hydrochloride treatment significantly impedes the proliferation of human colon cancer cell lines, HCT116 and RKO. The colony formation efficiency in HCT116 and RKO cells Is significantly reduced after treatment of PDK4-IN-1[1]. PDK4-IN-1 (Compound 8c; 10-50 μM; 24 hours; HCT116 and RKO cells) treatment dose-dependently increased apoptosis. PDK4-IN-1 decreases the expression of BCL-xL and increases the expression of BAX. Cleavage of PARP1 and caspase 3 are increased by PDK4-IN-1[1].
In vivo
PDK4-IN-1 (C57BL/6J mice) treatment significantly improves glucose tolerance[1]. Pre-incubation with PDK4-IN-1 (compound 8c) dose-dependently inhibits the release of β-hexosaminidase from IgE/antigen-activated BMMCs,
Chemical Properties
Molecular Weight393.87
FormulaC22H20ClN3O2
Cas No.2310262-11-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (317.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5389 mL12.6945 mL25.3891 mL126.9454 mL
5 mM0.5078 mL2.5389 mL5.0778 mL25.3891 mL
10 mM0.2539 mL1.2695 mL2.5389 mL12.6945 mL
20 mM0.1269 mL0.6347 mL1.2695 mL6.3473 mL
50 mM0.0508 mL0.2539 mL0.5078 mL2.5389 mL
100 mM0.0254 mL0.1269 mL0.2539 mL1.2695 mL

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